Phenotypes associated with this allele

• Allele Symbol: Tg(Nes-EGFP)33Enik
• Allele Name: transgene insertion 33, Grigori Enikolopov
• Allele ID: MGI:5523870
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tet1^tm1.1Gxu/Tet1^tm1.1Gxu Tg(Nes-EGFP)33Enik/0	involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J	MGI:5523879

Genotype
MGI:5523879

cn1

• Allelic Composition: Tet1^tm1.1Gxu/Tet1^tm1.1Gxu; Tg(Nes-EGFP)33Enik/0
• Genetic Background: involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:201001 )

• mice exhibit reduced adult subgranular zone neural progenitor pools compared with wild-type mice

• dentate gyrus primary neurospheres exhibit reduced self-renewal compared with wild-type cells

• however, differentiation potential is normal and galanin supplementation partially rescues proliferation

cellular

abnormal neuronal precursor proliferation ( J:201001 )

• mice exhibit reduced adult subgranular zone neural progenitor pools compared with wild-type mice

• dentate gyrus primary neurospheres exhibit reduced self-renewal compared with wild-type cells

• however, differentiation potential is normal and galanin supplementation partially rescues proliferation

abnormal DNA methylation ( J:201001 )

• neuronal progenitor cells exhibit hypermethylation compared with wild-type cells