Phenotypes associated with this allele

• Allele Symbol: Unc13a^tm4.1Bros
• Allele Name: targeted mutation 4.1, Nils Brose
• Allele ID: MGI:5523890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Unc13a^tm4.1Bros/Unc13a^tm4.1Bros	involves: FVB/N	MGI:5523893

Genotype
MGI:5523893

hm1

• Allelic Composition: Unc13a^tm4.1Bros/Unc13a^tm4.1Bros
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:201701 )

• prior to and after the onset of hearing, mice exhibit reduced rate of recovery of the fast releasing synaptic vesicle pool in the calyx of Held compared with wild-type mice

• after the onset of hearing, mice exhibit reduced rate of recovery of the fast and slow releasing synaptic vesicle pool in the calyx of Held compared with wild-type mice

abnormal CNS synaptic transmission ( J:201701 )

• slower recovery after excitatory postsynaptic currents depression, more pronounced after 300 Hz trains

decreased synaptic depression ( J:201701 )

• after the onset of hearing, mice exhibit aberrant short-term synaptic depression in the calyx of Held compared with wild-type mice

• however, short-term depression prior to the onset of hearing is normal