Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1.1(CAG-Smpd1)Jhkh}
• Allele Name: targeted mutation 1.1, Johannes Kornhuber
• Allele ID: MGI:5523896
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hprt1^tm1.1(CAG-Smpd1)Jhkh/Hprt1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5523916

Genotype
MGI:5523916

ht1

• Allelic Composition: Hprt1^{tm1.1(CAG-Smpd1)Jhkh}/Hprt1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal ceramide level ( J:199833 )

• high constitutive hippocampal ceramide concentrations

abnormal physiological response to xenobiotic ( J:199833 )

• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine

• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival

• however, treatment with antidepressants or fendiline normalizes behavior in corticosterone stressed or nonstressed mice

behavior/neurological

abnormal depression-related behavior ( J:199833 )

• mice exhibit depression-like behavior

• however, treatment with antidepressants or fendiline normalizes behavior in corticosterone stressed or nonstressed mice

nervous system

abnormal neuron differentiation ( J:199833 )

• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine

• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival

cellular

abnormal neuron differentiation ( J:199833 )

• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine

• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival