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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnr1tm2Ltz
targeted mutation 2, Beat Lutz
MGI:5523992
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cnr1tm2Ltz/Cnr1tm2Ltz B6.Cg-Cnr1tm2Ltz MGI:5524012
cn2
 		Cnr1tm2Ltz/Cnr1tm2.1Ltz
Neurod6tm1(cre)Kan/Neurod6+ 		B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz Neurod6tm1(cre)Kan MGI:5524013


Genotype
MGI:5524012
hm1
Allelic
Composition		 Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic
Background		 B6.Cg-Cnr1tm2Ltz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm2Ltz mutation (1 available); any Cnr1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
abnormal cued conditioning behavior ( J:199647 )
• mice exhibit impaired extinction of cued conditioning response with a more sustained conditioned freezing response
increased anxiety-related response ( J:199647 )
• mice spend less time in the open arms of an elevated plus maze and less time in the light compartment with longer latency until first entry in a light-dark test compared with wild-type mice

nervous system
decreased synaptic depression ( J:199647 )
• reduced depolarization-induced suppression of GABAergic inhibitory and glutamatergic excitatory postsynaptic currents in CA1 and basolateral amygdala neurons

homeostasis/metabolism




Genotype
MGI:5524013
cn2
Allelic
Composition		 Cnr1tm2Ltz/Cnr1tm2.1Ltz
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz Neurod6tm1(cre)Kan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm2.1Ltz mutation (0 available); any Cnr1 mutation (42 available)
Cnr1tm2Ltz mutation (1 available); any Cnr1 mutation (42 available)
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:199647 )
• in kainic acid treated mice but not as severely as in Cnr1tm2Ltz homozygotes

behavior/neurological
behavior/neurological phenotype ( J:199647 )
N
• mice spend normal amounts of time in the open arms of an elevated plus maze and the light compartment in a light-dark test
• mice exhibit normal susceptibility to kainic acid-induced seizures
abnormal cued conditioning behavior ( J:199647 )
• mice exhibit impaired extinction of cued conditioning response with a more sustained conditioned freezing response
• Background Sensitivity: however, cued conditioning is normal

nervous system
decreased synaptic depression ( J:199647 )
• reduced depolarization-induced suppression of GABAergic inhibitory postsynaptic currents in CA1 and basolateral amygdala neurons
• depolarization-induced suppression of glutamatergic excitatory postsynaptic currents in basolateral amygdala neurons has a prolonged time course

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:199647 )
• in kainic acid treated mice but not as severely as in Cnr1tm2Ltz homozygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory