Phenotypes associated with this allele

• Allele Symbol: Pla2g6^tm1Zyao
• Allele Name: targeted mutation 1, Zemin Yao
• Allele ID: MGI:5523997
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g6^tm1Zyao/Pla2g6^tm1Zyao	involves: 129S6/SvEvTac * C57BL/6	MGI:5524001

Genotype
MGI:5524001

hm1

• Allelic Composition: Pla2g6^tm1Zyao/Pla2g6^tm1Zyao
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased cholesterol level ( J:203038 )

• secretion of metabolically labeled apoB-100 in VLDL1 fractions is increased 2 fold from cultured hepatocytes isolated from mice on high fat diet (HFD) as compared to HFD-fed control

abnormal apolipoprotein level ( J:203038 )

♂ • secretion of apoB-100 as VLDL1 is increased 2 fold from hepatocytes isolated from mice on high fat diet (HFD) as compared to control on HFD

♂ • 40% increase in 35S labeled apoB-100 is found in VLDL1 plasma fractions from mice on high fat diet (HFD) as compared to control HFD-fed mice

reproductive system

male infertility ( J:203038 )

♂

vision/eye

blindness ( J:203038 )

♀ • some female mice are blind