All Phenotypes Pla2g6<tm1Zyao> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pla2g6^tm1Zyao
targeted mutation 1, Zemin Yao
MGI:5523997

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g6^tm1Zyao/Pla2g6^tm1Zyao	involves: 129S6/SvEvTac * C57BL/6	MGI:5524001

Allelic Composition	Pla2g6^tm1Zyao/Pla2g6^tm1Zyao
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g6^tm1Zyao mutation (1 available); any Pla2g6 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased cholesterol level ( J:203038 )

• secretion of metabolically labeled apoB-100 in VLDL1 fractions is increased 2 fold from cultured hepatocytes isolated from mice on high fat diet (HFD) as compared to HFD-fed control

abnormal apolipoprotein level ( J:203038 )

• secretion of apoB-100 as VLDL1 is increased 2 fold from hepatocytes isolated from mice on high fat diet (HFD) as compared to control on HFD

• 40% increase in 35S labeled apoB-100 is found in VLDL1 plasma fractions from mice on high fat diet (HFD) as compared to control HFD-fed mice

reproductive system

male infertility ( J:203038 )

vision/eye

blindness ( J:203038 )

• some female mice are blind

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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