Phenotypes associated with this allele

• Allele Symbol: Fbxw7^tm2Iaai
• Allele Name: targeted mutation 2, Iannis Aifantis
• Allele ID: MGI:5524152
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw7^tm2Iaai/Fbxw7^tm2Iaai	involves: C57BL/6	MGI:5524224
cn2	Fbxw7^tm2Iaai/Fbxw7^+ Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5524227
cn3	Fbxw7^tm2Iaai/Fbxw7^+ Tg(EIIa-cre)C5379Lmgd/0	involves: C57BL/6 * FVB/N	MGI:5524228

Genotype
MGI:5524224

hm1

• Allelic Composition: Fbxw7^tm2Iaai/Fbxw7^tm2Iaai
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, complete penetrance ( J:200006 )

• no mice are recovered from breeding heterozygotes

Genotype
MGI:5524227

cn2

• Allelic Composition: Fbxw7^tm2Iaai/Fbxw7⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

neoplasm

neoplasm ( J:200006 )

N • pIpC-treated mice do not develop leukemia

decreased tumor latency ( J:200006 )

• pIpC-treated mice infected with a retrovirus expression a truncated form of Notch1 that is constitutively cleaved in a ligand-independent manner or a Notch1 lacking the PEST domain exhibit shorted latency to development of leukemia

hematopoietic system

hematopoietic system phenotype ( J:200006 )

N • pIpC-treated mice exhibit normal numbers of hematopoietic stem cells and are more functionally competent than in cells from Fbxw7^tm1Iaai/Fbxw7⁺ Tg(Mx1-cre)1Cgn mice

immune system

immune system phenotype ( J:200006 )

N • pIpC-treated mice exhibit normal numbers of early T cell progenitors in the thymus

Genotype
MGI:5524228

cn3

• Allelic Composition: Fbxw7^tm2Iaai/Fbxw7⁺; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: C57BL/6 * FVB/N

embryo

embryo phenotype ( J:200006 )

N • mice do not develop developmental defects

neoplasm

neoplasm ( J:200006 )

N • mice do not develop tumors