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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrg1tm4.1Cbm
targeted mutation 4.1, Carmen Birchmeier
MGI:5524248
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nrg1tm4.1Cbm/Nrg1+ involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:5524257
cn2
 		Nrg1tm4Cbm/Nrg1tm4.1Cbm
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J MGI:5524256
cx3
 		Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+ 		involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6 MGI:5524258


Genotype
MGI:5524257
ht1
Allelic
Composition		 Nrg1tm4.1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle

nervous system




Genotype
MGI:5524256
cn2
Allelic
Composition		 Nrg1tm4Cbm/Nrg1tm4.1Cbm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (54 available)
Nrg1tm4Cbm mutation (0 available); any Nrg1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:199150 )
N
• mice exhibit normal myelination
abnormal muscle spindle morphology ( J:199150 )
• small diameter and few intrafusal fibers

behavior/neurological
impaired coordination ( J:199150 )
• on an inverted grid, mice loss their grip 5 times faster than control mice
abnormal gait ( J:199150 )
• impaired left/right coordination with frequent hopping

muscle
abnormal muscle spindle morphology ( J:199150 )
• small diameter and few intrafusal fibers




Genotype
MGI:5524258
cx3
Allelic
Composition		 Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation (0 available); any Bace1 mutation (30 available)
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
decreased muscle spindle number ( J:199150 )
• more pronounced in Nrg1tm4.1Cbm homozygotes

nervous system
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
decreased muscle spindle number ( J:199150 )
• more pronounced in Nrg1tm4.1Cbm homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory