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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C1galt1tm1.2Staka
targeted mutation 1.2, Satoru Takahashi
MGI:5524267
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		C1galt1tm1.2Staka/C1galt1tm1.2Staka involves: C57BL/6J * DBA/2 MGI:5524269
cn2
 		C1galt1tm1.1Staka/C1galt1tm1.2Staka
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * C57BL/6J * CBA * DBA/2 MGI:5524268


Genotype
MGI:5524269
hm1
Allelic
Composition		 C1galt1tm1.2Staka/C1galt1tm1.2Staka
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1tm1.2Staka mutation (0 available); any C1galt1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system




Genotype
MGI:5524268
cn2
Allelic
Composition		 C1galt1tm1.1Staka/C1galt1tm1.2Staka
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1tm1.1Staka mutation (0 available); any C1galt1 mutation (26 available)
C1galt1tm1.2Staka mutation (0 available); any C1galt1 mutation (26 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:202276 )
N
• pIpC-treated mice exhibit normal numbers of megakaryocytes in the bone marrow
abnormal megakaryocyte differentiation ( J:202276 )
• pIpC-treated mice exhibit abnormal morphology of terminally differentiated megakaryocytes
abnormal platelet morphology ( J:202276 )
• giant platelets with increased number of microtubule coils in pIpC-treated mice
thrombocytopenia ( J:202276 )
• severe in pIpC-treated mice whether or not mice are splenectomized
giant platelets ( J:202276 )
• in pIpC-treated mice

homeostasis/metabolism
increased bleeding time ( J:202276 )
• in pIpC-treated mice whether or not mice are splenectomized

cellular
abnormal megakaryocyte differentiation ( J:202276 )
• pIpC-treated mice exhibit abnormal morphology of terminally differentiated megakaryocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory