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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
targeted mutation 1, Charles L Sawyers
MGI:5524275
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sor+
Tg(Pbsn-cre)4Prb/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5524278
cn2
 		Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Tg(Pbsn-cre)4Prb/0 		involves: 129 * C57BL/6 * DBA/2 MGI:5524279
cn3
 		Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0 		involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:5524280


Genotype
MGI:5524278
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sor+
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
prostate gland ventral lobe hyperplasia ( J:200002 )
• focal ventral lobe hyperplasia after 1 year of age in 50% of mice

endocrine/exocrine glands
prostate gland ventral lobe hyperplasia ( J:200002 )
• focal ventral lobe hyperplasia after 1 year of age in 50% of mice




Genotype
MGI:5524279
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
prostate gland ventral lobe hyperplasia ( J:200002 )
• focal ventral lobe hyperplasia after 1 year of age in 50% of mice

endocrine/exocrine glands
prostate gland ventral lobe hyperplasia ( J:200002 )
• focal ventral lobe hyperplasia after 1 year of age in 50% of mice




Genotype
MGI:5524280
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:200002 )
• shortened survival compared with Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

reproductive system
enlarged prostate gland ( J:200002 )
• enlarged and hardened by 6 months
increased prostate gland adenocarcinoma incidence ( J:200002 )
• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
increased prostate intraepithelial neoplasia incidence ( J:200002 )
• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
abnormal prostate gland physiology ( J:200002 )
• proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

neoplasm
increased prostate gland adenocarcinoma incidence ( J:200002 )
• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
increased prostate intraepithelial neoplasia incidence ( J:200002 )
• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

renal/urinary system

growth/size/body
distended abdomen ( J:200002 )
• increased abdominal girth

endocrine/exocrine glands
enlarged prostate gland ( J:200002 )
• enlarged and hardened by 6 months
increased prostate gland adenocarcinoma incidence ( J:200002 )
• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
increased prostate intraepithelial neoplasia incidence ( J:200002 )
• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
abnormal prostate gland physiology ( J:200002 )
• proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory