Analysis Tools|
Allele Symbol Allele Name Allele ID |
Bcrtm1(BCR/ABL)Tsr targeted mutation 1, Theodora S Ross MGI:5524984 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of hematopoietic stem cells is decreased in young (1-3 month old) mice
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• bone marrow cells from mutant mice exhibit a competitive disadvantage when cotransplanted into lethally irradiated mice with wild type bone marrow cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are born at expected Mendelian rations and do not exhibit any gross abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice die between 6-12 months of age
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• prior to death mice exhibit neutrophilia and/or moncytosis
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• prior to death mice exhibit thrombocytopenia
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• prior to death mice exhibit lymphopenia
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• prior to death mice exhibit neutrophilia and/or moncytosis
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• prior to death mice exhibit neutrophilia and/or moncytosis
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• prior to death mice exhibit lymphopenia
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• prior to death mice exhibit neutrophilia and/or moncytosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice remained disease free throughout observation period (10-12 months)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bone marrow cells from mutant mice exhibit an engraftment advantage when cotransplanted into lethally irradiated mice with wild type bone marrow cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no hematopoietic abnormalities observed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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