Analysis Tools
mortality/aging
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• reduction in survival rate beginning around 9 months of age
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growth/size/body
weight loss
(
J:197198
)
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• weight loss by 6 months of age to similar extent as in either single mutant mice
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behavior/neurological
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• abnormal grooming behavior starting around 9 months of age as evident by dull rough coats
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• at 12 months of age, 88% of mutants exhibit cupping of the hind paws and bilaterally pulling of the hind paws toward the abdomen when suspended by the tail compared to 33% of wild-type mice
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• by 12 months of age, mutants show a hunched back or arched posture when sitting and walking
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• 12 month old mutants exhibit an usual gait in which the mouse holds its body near the walking surface and takes wide shortened steps
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immune system
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• expression analysis indicates neuroinflammation, with activated astrocytes and microglia seen in close proximity of amyloid deposits and neurofibrillary tangles; activated microglia are seen before Danish amyloid deposition and correlates with tau deposition
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nervous system
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• beginning around 6-7 months of age, mutants show amyloid deposition primarily in leptomeningeal cerebellar vessels and later developing extensive amyloid lesions in the parenchyma and vasculature of the neocortex, hippocampus, and cerebellum
• parenchymal amyloid deposition is most prominent in the CA3 and CA2 regions and the hilus of the hippocampus
|
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• tau deposits are predominately seen in the hippocampus, piriform cortex, brain stem, spinal cord, and the cerebellum
• tau accumulation is enhanced compared to single Tg(Prnp-MAPT*P301L)#Ruvi mice that occurs before extracellular deposition of Danish amyloid plaques
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• by 6 months of age, synaptophysin levels are decreased, indicating synaptic degeneration; this is seen earlier and with a more severe loss of synaptophysin than in either single mutant and occurs before the detection of amyloid plaques or tau pathology
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homeostasis/metabolism
|
• beginning around 6-7 months of age, mutants show amyloid deposition primarily in leptomeningeal cerebellar vessels and later developing extensive amyloid lesions in the parenchyma and vasculature of the neocortex, hippocampus, and cerebellum
• parenchymal amyloid deposition is most prominent in the CA3 and CA2 regions and the hilus of the hippocampus
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cerebral amyloid angiopathy | DOID:9246 | J:197198 | ||
