Phenotypes associated with this allele

• Allele Symbol: Agrp^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5526035
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agrp^tm1Dgen/Agrp^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:5526039

Genotype
MGI:5526039

hm1

• Allelic Composition: Agrp^tm1Dgen/Agrp^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:199803 )

N • similar amount of food intake to control littermates

growth/size/body

growth/size/body region phenotype ( J:199803 )

N • similar body composition to control animals

N • no significant fasting-induced loss

decreased lean body mass ( J:199803 )

• greater fasting-induced loss

increased susceptibility to weight loss ( J:199803 )

• greater fasting-induced loss

adipose tissue

adipose tissue phenotype ( J:199803 )

N • no significant fasting-induced loss of white or brown adipose tissue compare to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:199803 )

N • similar change in insulin and glucose levels compared to control littermates after fasting for 30 hours

N • similar increase to control after fasting for 30 hours and concurrently given leptin treatment

decreased circulating ketone body level ( J:199803 )

• significantly lower than controls after 36 hours of fasting

decreased circulating VLDL triglyceride level ( J:199803 )

• lower than control animals after fasting for 36 hours

increased noradrenaline level ( J:199803 )

• significantly higher in the liver after fasting for 30-hour compared to fasted controls

• significantly higher hepatic noradrenaline turnover rate in fasted mice

decreased liver triglyceride level ( J:199803 )

liver/biliary system

decreased liver triglyceride level ( J:199803 )

abnormal liver physiology ( J:199803 )

• significantly higher liver noradrenaline turnover rate after fasting for 30-hour

• release from the liver is reduced in fasted mice compared to fasted controls

• leptin treatment fails to increase liver noradrenaline levels in fasted mice