Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-KRAS*G12V,-luc)#Lche
• Allele Name: transgene insertion, Lukas C Heukamp
• Allele ID: MGI:5526090
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Del(15Krt7-Krt18)1Tmm/+ Igs11^tm1Tmm/Igs11^+ Krt1c^tm1Tmm/Krt1c^+ Tg(ACTB-KRAS*G12V,-luc)#Lche/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5527273
cx2	Del(15Krt7-Krt18)1Tmm/+ Tg(ACTB-KRAS*G12V,-luc)#Lche/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5527266
tg3	Tg(ACTB-KRAS*G12V,-luc)#Lche/0	involves: C57BL/6 * FVB/N	MGI:5526091

Genotype
MGI:5527273

cn1

• Allelic Composition: Del(15Krt7-Krt18)1Tmm/+; Igs11^tm1Tmm/Igs11⁺; Krt1c^tm1Tmm/Krt1c⁺; Tg(ACTB-KRAS*G12V,-luc)#Lche/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice

increased lung adenoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

increased lung adenocarcinoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

respiratory system

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice

increased lung adenoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

increased lung adenocarcinoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

Genotype
MGI:5527266

cx2

• Allelic Composition: Del(15Krt7-Krt18)1Tmm/+; Tg(ACTB-KRAS*G12V,-luc)#Lche/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

neoplasm

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• tumor load and size of AdCre treated mice is similar to that seen in single Tg(Actb-KRAS*G12V,-luc)#Lche mice

respiratory system

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• tumor load and size of AdCre treated mice is similar to that seen in single Tg(Actb-KRAS*G12V,-luc)#Lche mice

Genotype
MGI:5526091

tg3

• Allelic Composition: Tg(ACTB-KRAS*G12V,-luc)#Lche/0
• Genetic Background: involves: C57BL/6 * FVB/N

neoplasm

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors after 6-8 weeks

increased lung adenoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

increased lung adenocarcinoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

respiratory system

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors after 6-8 weeks

increased lung adenoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

increased lung adenocarcinoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:199528