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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pde8btm1Dgen
targeted mutation 1, Deltagen
MGI:5526098
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pde8btm1Dgen/Pde8btm1Dgen B6.129P2-Pde8btm1Dgen MGI:5526099
cx2
 		Pde8atm1Dgen/Pde8atm1Dgen
Pde8btm1Dgen/Pde8btm1Dgen 		involves: 129P2/OlaHsd * C57BL/6 MGI:5526100


Genotype
MGI:5526099
hm1
Allelic
Composition		 Pde8btm1Dgen/Pde8btm1Dgen
Genetic
Background		 B6.129P2-Pde8btm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde8btm1Dgen mutation (0 available); any Pde8b mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased urine corticosterone level ( J:203335 )
• under basal and stressed conditions
decreased physiological sensitivity to xenobiotic ( J:203335 )
• PF-04957325 (a PDE8-selective inhibitor) has a partial affect on basal steroid production compared to in wild-type cells

renal/urinary system
increased urine corticosterone level ( J:203335 )
• under basal and stressed conditions




Genotype
MGI:5526100
cx2
Allelic
Composition		 Pde8atm1Dgen/Pde8atm1Dgen
Pde8btm1Dgen/Pde8btm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde8atm1Dgen mutation (2 available); any Pde8a mutation (55 available)
Pde8btm1Dgen mutation (0 available); any Pde8b mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:203335 )
• PF-04957325 (a PDE8-selective inhibitor) has no affect on basal steroid production unlike in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory