All Phenotypes Usp7<tm2Wgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Usp7^tm2Wgu
targeted mutation 2, Wei Gu
MGI:5526104

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp7^tm2Wgu/Usp7^tm2Wgu	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5526847
cn2	Trp53^tm1Tyj/Trp53^tm1Tyj Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5526849
cn3	Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5526848

Allelic Composition	Usp7^tm2Wgu/Usp7^tm2Wgu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp7^tm2Wgu mutation (0 available); any Usp7 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203102 )

N	• all mice are alive at weaning

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (244 available)
Usp7^tm2Wgu mutation (0 available); any Usp7 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:203102 )

nervous system

nervous system phenotype ( J:203102 )

N	• mice exhibit normal forebrain, midbrain and cerebellum size, cerebellum thickness and neural cell density

open neural tube ( J:203102 )

• in some mice

embryo

open neural tube ( J:203102 )

• in some mice

Allelic Composition	Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Usp7^tm2Wgu mutation (0 available); any Usp7 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:203102 )

• 15 of 21 newborn mice die soon after birth

• all mice die by P1

nervous system

decreased brain size ( J:203102 )

• at E18.5

abnormal forebrain morphology ( J:203102 )

• flat with an almost a right angle at the midbrain junction

decreased forebrain size ( J:203102 )

• at E18.5

enlarged third ventricle ( J:203102 )

• at E18.5

thickened cerebral cortex ( J:203102 )

• at E18.5

absent cerebellum ( J:203102 )

• mostly missing at the midline at E18.5

decreased neuron number ( J:203102 )

• at E18.5

behavior/neurological

absent gastric milk in neonates ( J:203102 )

abnormal motor capabilities/coordination/movement ( J:203102 )

• uncoordinated movement at birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24