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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Riox2tm1Mtsun
targeted mutation 1, Makoto Tsuneoka
MGI:5526952
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Riox2tm1Mtsun/Riox2tm1Mtsun B6CrSlc.Cg-Riox2tm1Mtsun MGI:5526980


Genotype
MGI:5526980
hm1
Allelic
Composition
Riox2tm1Mtsun/Riox2tm1Mtsun
Genetic
Background
B6CrSlc.Cg-Riox2tm1Mtsun
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Riox2tm1Mtsun mutation (0 available); any Riox2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the bronchoalveolar lavage fluid of mice exposed to house dust mites
• in the bronchoalveolar lavage fluid of mice exposed to house dust mites
• mice exposed to house dust mites fail to exhibit an increase in IgE unlike wild-type mice
• mice exposed to house dust mites fail to exhibit a decrease in IFNG unlike wild-type mice
• mice exposed to house dust mites fail to exhibit an increase in IL4 unlike wild-type mice
• mice exposed to house dust mites exhibit reduced inflammation with reduced increase in eosinophil, neutrophil and macrophage cell numbers compared with wild-type mice and fail to exhibit an increase in serum IL4 and IgE or a decrease in IFNG unlike wild-type mice

respiratory system
• house dust mite-exposed mice treated with methacholine exhibit decreased airway hyperresponsiveness unlike wild-type mice

homeostasis/metabolism
• mice exposed to house dust mites fail to exhibit a decrease in IFNG unlike wild-type mice
• mice exposed to house dust mites fail to exhibit an increase in IL4 unlike wild-type mice
• house dust mite-exposed mice treated with methacholine exhibit decreased airway hyperresponsiveness unlike wild-type mice

hematopoietic system
• in the bronchoalveolar lavage fluid of mice exposed to house dust mites
• in the bronchoalveolar lavage fluid of mice exposed to house dust mites
• mice exposed to house dust mites fail to exhibit an increase in IgE unlike wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory