Phenotypes associated with this allele

• Allele Symbol: Stip1^tm1.2Mamp
• Allele Name: targeted mutation 1.2, Marco A M Prado
• Allele ID: MGI:5527075
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stip1^tm1.2Mamp/Stip1^tm1.2Mamp	involves: C57BL/6	MGI:5527080
ht2	Stip1^tm1.2Mamp/Stip1^+	involves: C57BL/6	MGI:5527081

Genotype
MGI:5527080

hm1

• Allelic Composition: Stip1^tm1.2Mamp/Stip1^tm1.2Mamp
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:201097 )

• no mice are present at E10.5

embryonic lethality, incomplete penetrance ( J:201097 )

• fewer than expected mice are present at E3.5 and E10.5

• however, transgenic expression of Stip1 rescues lethality

cellular

increased cell death ( J:201097 )

• in mouse embryonic fibroblasts after 8 to 10 days in culture

increased embryonic tissue cell apoptosis ( J:201097 )

• in E10.5 embryos

decreased fibroblast proliferation ( J:201097 )

• in mouse embryonic fibroblasts

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in mouse embryonic fibroblasts after 8 to 10 days in culture

embryo

increased embryonic tissue cell apoptosis ( J:201097 )

• in E10.5 embryos

abnormal limb bud morphology ( J:201097 )

• poorly formed

abnormal neural tube morphology ( J:201097 )

• poorly formed

abnormal placenta physiology ( J:201097 )

• acute inflammation in and around the placental labyrinth without infection unlike in wild-type mice

limbs/digits/tail

abnormal limb bud morphology ( J:201097 )

• poorly formed

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in mouse embryonic fibroblasts after 8 to 10 days in culture

nervous system

abnormal neural tube morphology ( J:201097 )

• poorly formed

immune system

increased acute inflammation ( J:201097 )

• acute inflammation in and around the placental labyrinth without infection unlike in wild-type mice

Genotype
MGI:5527081

ht2

• Allelic Composition: Stip1^tm1.2Mamp/Stip1⁺
• Genetic Background: involves: C57BL/6

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:201097 )

• following middle cerebral artery occlusion

nervous system

increased susceptibility to ischemic brain injury ( J:201097 )

• following middle cerebral artery occlusion, mice exhibit increased mortality, infarct volume and decreased dexterity to removing tape on their ipsilateral ischemic side compared with wild-type mice

• however, the mice that survive stroke injury recover normally

increased cerebral infarct size ( J:201097 )

• following middle cerebral artery occlusion

abnormal astrocyte physiology ( J:201097 )

• increased double-strand breaks in astrocytes

• however, astrocytes exhibit normal proliferation and response to oxygen and glucose deprivation

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in astrocytes

increased susceptibility to ischemic brain injury ( J:201097 )

• following middle cerebral artery occlusion, mice exhibit increased mortality, infarct volume and decreased dexterity to removing tape on their ipsilateral ischemic side compared with wild-type mice

• however, the mice that survive stroke injury recover normally

increased cerebral infarct size ( J:201097 )

• following middle cerebral artery occlusion

cellular

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in astrocytes