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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Vav1-cre)#Cgp
transgene insertion, Cristin G Print
MGI:5527187
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Jak2tm2.1Jlvl/Jak2+
Tg(Vav1-cre)#Cgp/0
involves: 129S2/SvPas * C57BL/6NTac MGI:5538507
cn2
Mirc27em1Hhzg/Mirc27em1Hhzg
Tg(Vav1-cre)#Cgp/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj MGI:7413041
cn3
Mirc30em1Hhzg/Mirc30em1Hhzg
Tg(Vav1-cre)#Cgp/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj MGI:7413042
cn4
Bcrtm1(BCR/ABL)Tsr/Bcr+
Runx1tm3Dow/Runx1+
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 MGI:5525100
cn5
Bcrtm1(BCR/ABL)Tsr/Bcrtm1(BCR/ABL)Tsr
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 MGI:5527191
cn6
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 MGI:5527200
cn7
Otud5tm1Vmd/Otud5tm1Vmd
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 MGI:5896451
cn8
Phf6em1Wencc/Y
Tg(Vav1-cre)#Cgp/0
Not Specified MGI:7280786
cn9
Phf6em1Wencc/Phf6em1Wencc
Tg(Vav1-cre)#Cgp/0
Not Specified MGI:7280785


Genotype
MGI:5538507
cn1
Allelic
Composition
Jak2tm2.1Jlvl/Jak2+
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm2.1Jlvl mutation (0 available); any Jak2 mutation (59 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mild at 6 weeks due to an increase in erythroblasts and myeloid cells
• severe at 12 weeks due to an increase in erythroblasts and myeloid cells
• 3-fold at 6 weeks
• 8-fold at 12 weeks
• increased CFU-GM in the bone marrow, but not spleen
• in the spleen
• increased BFU-E in the spleen and bone marrow
• however, CFU-E numbers are normal in the bone marrow and spleen
• mature erythroblasts
• slightly at 2 weeks
• however, aged mice exhibit a drop in erythrocyte cell number to normal levels
• at 2 to 3 months and plateau for 5 months
• however, aged mice exhibit a drop in hematocrit to normal levels
• at 2 months and plateau for 4 months
• however, aged mice exhibit a drop in hemoglobin to normal levels
• severe
• severe, plateau for 6 months before decreasing in aged mice
• early and more so in aged mice
• at 3 months, mice exhibit increased LSK (2.3 times) and SLAM (2 time) cells in the bone marrow compared with control mice
• at 3 months, mice exhibit increased Lin- (1.5-fold), LSK (1.7-fold) and SLAM (3.7-fold) cells in the spleen compared with control mice
• 1, 3 and 6 month old mice exhibit a 3-, 4- and 5-fold increase, respectively, in total Lin- cells (bone marrow and spleen) compared with control mice
• at 3 months, mice exhibit a 3-fold and 7-fold increase in LSK and SLAM cells, respectively, compared with wild-type mice
• at 6 months, mice exhibit a 4-fold and 6-fold increase in LSK and SLAM cells, respectively, compared with wild-type mice
• in aged mice
• in transplantation experiments, bone marrow cells promotes hematopoietic cell proliferation compared to control cells
• however, IFNalpha treatment suppresses increased cell proliferation

skeleton
• in aged mice

immune system
• mild at 6 weeks due to an increase in erythroblasts and myeloid cells
• severe at 12 weeks due to an increase in erythroblasts and myeloid cells
• 3-fold at 6 weeks
• 8-fold at 12 weeks
• increased CFU-GM in the bone marrow, but not spleen
• in the spleen
• early and more so in aged mice
• in aged mice

growth/size/body
• mild at 6 weeks due to an increase in erythroblasts and myeloid cells
• severe at 12 weeks due to an increase in erythroblasts and myeloid cells
• 3-fold at 6 weeks
• 8-fold at 12 weeks




Genotype
MGI:7413041
cn2
Allelic
Composition
Mirc27em1Hhzg/Mirc27em1Hhzg
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc27em1Hhzg mutation (0 available); any Mirc27 mutation (3 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal blood and spleen CD5+ B cell numbers, spleen weight, NK cell development, early B-cell development, and immune cell homeostasis and function

neoplasm
N
• mice exhibit normal tumor development




Genotype
MGI:7413042
cn3
Allelic
Composition
Mirc30em1Hhzg/Mirc30em1Hhzg
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc30em1Hhzg mutation (0 available); any Mirc30 mutation (4 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased percentage
• increased CD5+ B cell in the blood of 10-month-old mice
• increased percentage
• partially block NK cell development at the stage III to stage IV transition

neoplasm

growth/size/body

hematopoietic system
• increased percentage
• increased CD5+ B cell in the blood of 10-month-old mice
• increased percentage
• partially block NK cell development at the stage III to stage IV transition




Genotype
MGI:5525100
cn4
Allelic
Composition
Bcrtm1(BCR/ABL)Tsr/Bcr+
Runx1tm3Dow/Runx1+
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcrtm1(BCR/ABL)Tsr mutation (1 available); any Bcr mutation (51 available)
Runx1tm3Dow mutation (0 available); any Runx1 mutation (34 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die between 6-12 months of age

hematopoietic system
• prior to death mice exhibit neutrophilia and/or moncytosis
• prior to death mice exhibit thrombocytopenia
• prior to death mice exhibit lymphopenia
• prior to death mice exhibit neutrophilia and/or moncytosis

immune system
• prior to death mice exhibit neutrophilia and/or moncytosis
• prior to death mice exhibit lymphopenia
• prior to death mice exhibit neutrophilia and/or moncytosis




Genotype
MGI:5527191
cn5
Allelic
Composition
Bcrtm1(BCR/ABL)Tsr/Bcrtm1(BCR/ABL)Tsr
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcrtm1(BCR/ABL)Tsr mutation (1 available); any Bcr mutation (51 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice remained disease free throughout observation period (10-12 months)




Genotype
MGI:5527200
cn6
Allelic
Composition
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcrtm1(BCR/ABL)Tsr mutation (1 available); any Bcr mutation (51 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells from mutant mice exhibit an engraftment advantage when cotransplanted into lethally irradiated mice with wild type bone marrow cells




Genotype
MGI:5896451
cn7
Allelic
Composition
Otud5tm1Vmd/Otud5tm1Vmd
Tg(Vav1-cre)#Cgp/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otud5tm1Vmd mutation (0 available); any Otud5 mutation (9 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased IL17+ type 3 innate lymphoid cells

hematopoietic system
• increased IL17+ type 3 innate lymphoid cells




Genotype
MGI:7280786
cn8
Allelic
Composition
Phf6em1Wencc/Y
Tg(Vav1-cre)#Cgp/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6em1Wencc mutation (0 available); any Phf6 mutation (12 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

endocrine/exocrine glands
• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body
• at age 18 months
• normal spleen weight and histology at age 8-12 weeks

hematopoietic system
N
• normal white blood cell count (WBC) at age 8 weeks
• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks
• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks
• at age 18 months
• normal spleen weight and histology at age 8-12 weeks
• in bone marrow at age 8-12 weeks
• in spleen red pulp at age 18 months
• reduced number of LK and Lin- cells at age 8-12 weeks
• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks
• in bone marrow at age 8-12 weeks
• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months
• hyperplastic in bone marrow at age 18 months
• in blood at age 18 months
• more B220+ cells at ages 8-12 weeks and 18 months
• normal percentage of B cells in spleen at age 8-12 weeks
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks
• in blood at age 18 months
• reduced in thymus at age 8-12 weeks
• at age 8-12 weeks and in spleen at age 18 months
• normal percentage in spleen at age 8-12 weeks
• at age 8-12 weeks and in spleen at age 18 months
• reduced percentage in spleen at age 8-12 weeks
• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months
• in bone marrow at age 8-12 weeks
• reduced percentage of T cells at age 8-12 weeks
• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months
• increased percentage of CD4+ T cells at age 18 months
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months
• normal percentage of CD4+ T cells at age 8-12 weeks
• normal percentage of B cells at age 8-12 weeks

immune system
N
• normal spleen and thymus weight and histology at age 8-12 weeks
• normal percentage of B cells in spleen at age 8-12 weeks
• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks
• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks
• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks
• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks
• at age 18 months
• normal spleen weight and histology at age 8-12 weeks
• in bone marrow at age 8-12 weeks
• more B220+ cells at ages 8-12 weeks and 18 months
• normal percentage of B cells in spleen at age 8-12 weeks
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks
• in blood at age 18 months
• reduced in thymus at age 8-12 weeks
• at age 8-12 weeks and in spleen at age 18 months
• normal percentage in spleen at age 8-12 weeks
• at age 8-12 weeks and in spleen at age 18 months
• reduced percentage in spleen at age 8-12 weeks
• reduced percentage of T cells at age 8-12 weeks
• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months
• increased percentage of CD4+ T cells at age 18 months
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months
• normal percentage of CD4+ T cells at age 8-12 weeks
• normal percentage of B cells at age 8-12 weeks

skeleton
N
• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months




Genotype
MGI:7280785
cn9
Allelic
Composition
Phf6em1Wencc/Phf6em1Wencc
Tg(Vav1-cre)#Cgp/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6em1Wencc mutation (0 available); any Phf6 mutation (12 available)
Tg(Vav1-cre)#Cgp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal spleen and thymus weight and histology at age 8-12 weeks
• normal percentage of B cells in spleen at age 8-12 weeks
• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks
• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks
• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks
• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks
• at age 18 months
• normal spleen weight and histology at age 8-12 weeks
• in bone marrow at age 8-12 weeks
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks
• in blood at age 18 months
• reduced in thymus at age 8-12 weeks
• at age 8-12 weeks
• normal percentage in spleen at age 8-12 weeks
• at age 8-12 weeks
• reduced percentage in spleen at age 8-12 weeks
• more B220+ cells at ages 8-12 weeks and 18 months
• normal percentage of B cells in spleen at age 8-12 weeks
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks
• reduced percentage of T cells at age 8-12 weeks
• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months
• increased percentage of CD4+ T cells at age 18 months
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months
• normal percentage of CD4+ T cells at age 8-12 weeks
• normal percentage of B cells at age 8-12 weeks

hematopoietic system
• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks
• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks
• at age 18 months
• normal spleen weight and histology at age 8-12 weeks
• in bone marrow at age 8-12 weeks
• in spleen red pulp at age 18 months
• reduced number of LK and Lin- cells at age 8-12 weeks
• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks
• in bone marrow at age 8-12 weeks
• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months
• hyperplastic in bone marrow at age 18 months
• in blood at age 18 months
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks
• in blood at age 18 months
• reduced in thymus at age 8-12 weeks
• at age 8-12 weeks
• normal percentage in spleen at age 8-12 weeks
• at age 8-12 weeks
• reduced percentage in spleen at age 8-12 weeks
• more B220+ cells at ages 8-12 weeks and 18 months
• normal percentage of B cells in spleen at age 8-12 weeks
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks
• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months
• in bone marrow at age 8-12 weeks
• reduced percentage of T cells at age 8-12 weeks
• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months
• increased percentage of CD4+ T cells at age 18 months
• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months
• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months
• normal percentage of CD4+ T cells at age 8-12 weeks
• normal percentage of B cells at age 8-12 weeks

endocrine/exocrine glands
• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body
• at age 18 months
• normal spleen weight and histology at age 8-12 weeks

cellular
• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

skeleton
N
• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory