All Phenotypes Tg(Vav1-cre)#Cgp MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Jak2^tm2.1Jlvl/Jak2⁺ Tg(Vav1-cre)#Cgp/0	involves: 129S2/SvPas * C57BL/6NTac	MGI:5538507
cn2	Mirc27^em1Hhzg/Mirc27^em1Hhzg Tg(Vav1-cre)#Cgp/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj	MGI:7413041
cn3	Mirc30^em1Hhzg/Mirc30^em1Hhzg Tg(Vav1-cre)#Cgp/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj	MGI:7413042
cn4	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Runx1^tm3Dow/Runx1⁺ Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5525100
cn5	Bcr^{tm1(BCR/ABL)Tsr}/Bcr^{tm1(BCR/ABL)Tsr} Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5527191
cn6	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5527200
cn7	Otud5^tm1Vmd/Otud5^tm1Vmd Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5896451
cn8	Phf6^em1Wencc/Y Tg(Vav1-cre)#Cgp/0	Not Specified	MGI:7280786
cn9	Phf6^em1Wencc/Phf6^em1Wencc Tg(Vav1-cre)#Cgp/0	Not Specified	MGI:7280785

Allelic Composition	Jak2^tm2.1Jlvl/Jak2⁺ Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: 129S2/SvPas * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2^tm2.1Jlvl mutation (0 available); any Jak2 mutation (59 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:202234 )

• mild at 6 weeks due to an increase in erythroblasts and myeloid cells

• severe at 12 weeks due to an increase in erythroblasts and myeloid cells

increased spleen weight ( J:202234 )

• 3-fold at 6 weeks

• 8-fold at 12 weeks

abnormal definitive hematopoiesis ( J:202234 )

abnormal myelopoiesis ( J:202234 )

• increased CFU-GM in the bone marrow, but not spleen

myeloid hyperplasia ( J:202234 )

• in the spleen

extramedullary hematopoiesis ( J:202234 )

• in the liver

decreased bone marrow cell number ( J:202234 )

increased erythroid progenitor cell number ( J:202234 )

• increased BFU-E in the spleen and bone marrow

• however, CFU-E numbers are normal in the bone marrow and spleen

decreased erythroblast number ( J:202234 )

• mature erythroblasts

increased erythrocyte cell number ( J:202234 )

• slightly at 2 weeks

• however, aged mice exhibit a drop in erythrocyte cell number to normal levels

increased hematocrit ( J:202234 )

• at 2 to 3 months and plateau for 5 months

• however, aged mice exhibit a drop in hematocrit to normal levels

increased hemoglobin content ( J:202234 )

• at 2 months and plateau for 4 months

• however, aged mice exhibit a drop in hemoglobin to normal levels

microcytosis ( J:202234 )

• severe

thrombocytosis ( J:202234 )

• severe, plateau for 6 months before decreasing in aged mice

decreased B cell number ( J:202234 )

increased leukocyte cell number ( J:202234 )

• early and more so in aged mice

increased granulocyte number ( J:202234 )

reticulocytosis ( J:202234 )

increased hematopoietic stem cell number ( J:202234 )

• at 3 months, mice exhibit increased LSK (2.3 times) and SLAM (2 time) cells in the bone marrow compared with control mice

• at 3 months, mice exhibit increased Lin- (1.5-fold), LSK (1.7-fold) and SLAM (3.7-fold) cells in the spleen compared with control mice

• 1, 3 and 6 month old mice exhibit a 3-, 4- and 5-fold increase, respectively, in total Lin- cells (bone marrow and spleen) compared with control mice

• at 3 months, mice exhibit a 3-fold and 7-fold increase in LSK and SLAM cells, respectively, compared with wild-type mice

• at 6 months, mice exhibit a 4-fold and 6-fold increase in LSK and SLAM cells, respectively, compared with wild-type mice

spleen fibrosis ( J:202234 )

• in aged mice

abnormal bone marrow cell physiology ( J:202234 )

• in transplantation experiments, bone marrow cells promotes hematopoietic cell proliferation compared to control cells

• however, IFNalpha treatment suppresses increased cell proliferation

skeleton

myelofibrosis ( J:202234 )

• in aged mice

immune system

enlarged spleen ( J:202234 )

• mild at 6 weeks due to an increase in erythroblasts and myeloid cells

• severe at 12 weeks due to an increase in erythroblasts and myeloid cells

increased spleen weight ( J:202234 )

• 3-fold at 6 weeks

• 8-fold at 12 weeks

abnormal myelopoiesis ( J:202234 )

• increased CFU-GM in the bone marrow, but not spleen

myeloid hyperplasia ( J:202234 )

• in the spleen

decreased B cell number ( J:202234 )

increased leukocyte cell number ( J:202234 )

• early and more so in aged mice

increased granulocyte number ( J:202234 )

spleen fibrosis ( J:202234 )

• in aged mice

growth/size/body

enlarged spleen ( J:202234 )

• mild at 6 weeks due to an increase in erythroblasts and myeloid cells

• severe at 12 weeks due to an increase in erythroblasts and myeloid cells

increased spleen weight ( J:202234 )

• 3-fold at 6 weeks

• 8-fold at 12 weeks

Allelic Composition	Mirc27^em1Hhzg/Mirc27^em1Hhzg Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc27^em1Hhzg mutation (0 available); any Mirc27 mutation (3 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:320883 )

N	• mice exhibit normal blood and spleen CD5+ B cell numbers, spleen weight, NK cell development, early B-cell development, and immune cell homeostasis and function

neoplasm

neoplasm ( J:320883 )

N	• mice exhibit normal tumor development

Allelic Composition	Mirc30^em1Hhzg/Mirc30^em1Hhzg Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc30^em1Hhzg mutation (0 available); any Mirc30 mutation (4 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased spleen weight ( J:320883 )

increased pro-B cell number ( J:320883 )

• increased percentage

increased B cell number ( J:320883 )

• increased CD5+ B cell in the blood of 10-month-old mice

increased pre-B cell number ( J:320883 )

• increased percentage

abnormal NK cell morphology ( J:320883 )

• partially block NK cell development at the stage III to stage IV transition

neoplasm

increased chronic lymphocytic leukemia incidence ( J:320883 )

growth/size/body

increased spleen weight ( J:320883 )

hematopoietic system

increased spleen weight ( J:320883 )

increased pro-B cell number ( J:320883 )

• increased percentage

increased B cell number ( J:320883 )

• increased CD5+ B cell in the blood of 10-month-old mice

increased pre-B cell number ( J:320883 )

• increased percentage

abnormal NK cell morphology ( J:320883 )

• partially block NK cell development at the stage III to stage IV transition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:320883

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Runx1^tm3Dow/Runx1⁺ Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Runx1^tm3Dow mutation (0 available); any Runx1 mutation (34 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203111 )

• 50% of mice die between 6-12 months of age

hematopoietic system

increased neutrophil cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

thrombocytopenia ( J:203111 )

• prior to death mice exhibit thrombocytopenia

decreased lymphocyte cell number ( J:203111 )

• prior to death mice exhibit lymphopenia

increased monocyte cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

immune system

increased neutrophil cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

decreased lymphocyte cell number ( J:203111 )

• prior to death mice exhibit lymphopenia

increased monocyte cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr^{tm1(BCR/ABL)Tsr} Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203111 )

• mice remained disease free throughout observation period (10-12 months)

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell physiology ( J:203111 )

• bone marrow cells from mutant mice exhibit an engraftment advantage when cotransplanted into lethally irradiated mice with wild type bone marrow cells

Allelic Composition	Otud5^tm1Vmd/Otud5^tm1Vmd Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otud5^tm1Vmd mutation (0 available); any Otud5 mutation (9 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 17 cell differentiation ( J:219495 )

• increased IL17+ type 3 innate lymphoid cells

hematopoietic system

abnormal T-helper 17 cell differentiation ( J:219495 )

• increased IL17+ type 3 innate lymphoid cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

hematopoietic system

hematopoietic system phenotype ( J:278804 )

N	• normal white blood cell count (WBC) at age 8 weeks

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

• in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

• reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

• hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

• in blood at age 18 months

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• reduced percentage in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

immune system

immune system phenotype ( J:278804 )

• normal spleen and thymus weight and histology at age 8-12 weeks

• normal percentage of B cells in spleen at age 8-12 weeks

• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• reduced percentage in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

N	• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months

Allelic Composition	Phf6^em1Wencc/Phf6^em1Wencc Tg(Vav1-cre)#Cgp/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6^em1Wencc mutation (0 available); any Phf6 mutation (12 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:278804 )

• normal spleen and thymus weight and histology at age 8-12 weeks

• normal percentage of B cells in spleen at age 8-12 weeks

• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• reduced percentage in spleen at age 8-12 weeks

increased leukocyte cell number ( J:278804 )

• at age 8 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

hematopoietic system

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

• in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

• reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

• hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

• in blood at age 18 months

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• reduced percentage in spleen at age 8-12 weeks

increased leukocyte cell number ( J:278804 )

• at age 8 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

N	• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months

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