Phenotypes associated with this allele

• Allele Symbol: Becn1^tm1.1Bflu
• Allele Name: targeted mutation 1.1, Binfeng Lu
• Allele ID: MGI:5527250
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Becn1^tm1.1Bflu/Becn1^tm1.1Bflu Tg(Cd4-cre)1Cwi/0	involves: 129S1/Sv * C57BL/6 * DBA/2	MGI:5527279

Genotype
MGI:5527279

cn1

• Allelic Composition: Becn1^tm1.1Bflu/Becn1^tm1.1Bflu; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:203090 )

• of CD4+ T cells following TCR stimulation

decreased T cell proliferation ( J:203090 )

• stimulated CD4+ T cell exhibit modestly reduced proliferation compared with control cells

decreased CD4-positive, alpha-beta T cell number ( J:203090 )

• less than 2-fold in untreated mice

• in MOG treated mice

decreased CD8-positive, alpha-beta T cell number ( J:203090 )

• more than 3-fold

abnormal CD4-positive, alpha-beta T cell physiology ( J:203090 )

• reduced survival and decreased proliferation of stimulated CD4+ T cells after 72 hours in culture

• CD4+ T cells cultured in TH0, TH1 and TH2 conditions exhibit increased susceptibility to cell death compared with control cells

• CD4+ T cells cultured in TH17 conditions exhibit decreased susceptibility to cell death compared with control cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:203090 )

• mice treated with MOG exhibit complete resistance to experimental autoimmune encephalomyelitis with a very minor decrease in total CD4+ T cells in the spleens and lymph nodes, a great reduction in IFNG-gamma+ CD4+ T cells, modestly reduced IL17+ CD4+ T cells and absence of CD4+ T cells infiltration in the central nervous system compared with control mice

cellular

increased T cell apoptosis ( J:203090 )

• of CD4+ T cells following TCR stimulation

decreased T cell proliferation ( J:203090 )

• stimulated CD4+ T cell exhibit modestly reduced proliferation compared with control cells

hematopoietic system

increased T cell apoptosis ( J:203090 )

• of CD4+ T cells following TCR stimulation

decreased T cell proliferation ( J:203090 )

• stimulated CD4+ T cell exhibit modestly reduced proliferation compared with control cells

decreased CD4-positive, alpha-beta T cell number ( J:203090 )

• less than 2-fold in untreated mice

• in MOG treated mice

decreased CD8-positive, alpha-beta T cell number ( J:203090 )

• more than 3-fold

abnormal CD4-positive, alpha-beta T cell physiology ( J:203090 )

• reduced survival and decreased proliferation of stimulated CD4+ T cells after 72 hours in culture

• CD4+ T cells cultured in TH0, TH1 and TH2 conditions exhibit increased susceptibility to cell death compared with control cells

• CD4+ T cells cultured in TH17 conditions exhibit decreased susceptibility to cell death compared with control cells