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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt1ctm1Tmm
targeted mutation 1, Thomas M Magin
MGI:5527256
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Del(15Krt7-Krt18)1Tmm/+
Igs11tm1Tmm/Igs11+
Krt1ctm1Tmm/Krt1c+
Tg(ACTB-KRAS*G12V,-luc)#Lche/0 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5527273


Genotype
MGI:5527273
cn1
Allelic
Composition		 Del(15Krt7-Krt18)1Tmm/+
Igs11tm1Tmm/Igs11+
Krt1ctm1Tmm/Krt1c+
Tg(ACTB-KRAS*G12V,-luc)#Lche/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:199528 )
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment
• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice
increased lung adenoma incidence ( J:199528 )
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas
increased lung adenocarcinoma incidence ( J:199528 )
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

respiratory system
increased lung tumor incidence ( J:199528 )
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment
• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice
increased lung adenoma incidence ( J:199528 )
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas
increased lung adenocarcinoma incidence ( J:199528 )
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas




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12/10/2024
MGI 6.24 		The Jackson Laboratory