Phenotypes associated with this allele

• Allele Symbol: Cyfip2^M1N
• Allele Name: mutation 1, National Institutes of Health
• Allele ID: MGI:5527294
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyfip2^M1N/Cyfip2^M1N	C57BL/6N	MGI:5527328
ht2	Cyfip2^M1N/Cyfip2^+	(C57BL/6N x C57BL/6J)F1	MGI:5527331
ht3	Cyfip2^M1N/Cyfip2^tm1a(EUCOMM)Wtsi	C57BL/6N-Cyfip2^M1N/Cyfip2^tm1a(EUCOMM)Wtsi	MGI:5527330

Genotype
MGI:5527328

hm1

• Allelic Composition: Cyfip2^M1N/Cyfip2^M1N
• Genetic Background: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:203183 )

• fewer total spines and spines of each class compared with C57BL/6J mice

decreased miniature excitatory postsynaptic current frequency ( J:203183 )

• decreased miniature excitatory postsynaptic current frequency compared with C57BL/6J mice

• however, amplitude is normal

behavior/neurological

impaired behavioral response to cocaine ( J:203183 )

• compared with C57BL/6J mice

• however, cocaine metabolism is the same as in C57BL/6J mice

Genotype
MGI:5527331

ht2

• Allelic Composition: Cyfip2^M1N/Cyfip2⁺
• Genetic Background: (C57BL/6N x C57BL/6J)F1

behavior/neurological

impaired behavioral response to cocaine ( J:203183 )

• compared with C57BL/6J mice

Genotype
MGI:5527330

ht3

• Allelic Composition: Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0436_2_A04

behavior/neurological

enhanced behavioral response to cocaine ( J:203183 )

• compared with Cyfip2^m1N homozygotes