Analysis Tools
mortality/aging
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• despite being present in Mendelian ratios at E15, mice die before birth
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nervous system
| N |
• neuron proliferation in the central nervous system is normal
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• poorly vascularized brains corresponding to regions of increased apoptosis
• abnormal vascular patterning and larger vessel diameter at E16.5 and E18.5
• glomeruloid terminal structures form in the subventricular zone
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• at E13.5 in the dorsal root ganglion at the thoracic and lumbar levels affecting all neuronal subtypes
• at E14.5 in vestibular and glossopharyngeal ganglia
• at E15.5 and E16.5 in the ventral neuroepithelium, retina, thalamus and cortex
• at E18.5 in the neuroepithelium, subventricular zone, cingulum and dorsal subiculum of the hippocampus, cortex, caudate putamen, ventroposterolateral and medial thalamic nuclei and nucleus reuniens
• more severe during development
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• hippocampal nerves exhibit altered response to BDNF with increased axonal length, number of dendrites, decreased branching dendrites and decreased dendrite length compared with wild-type cells
• however, axonal growth in response to BDNF is normal
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• at E18.5
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• at E18.5
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• in the lumbar spinal cord at E18.5
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• increased number of axon branches and axonal length in untreated neurons
• however, axonal growth in response to BDNF is normal
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• hippocampal nerves exhibit altered response to BDNF with increased axonal length, number of dendrites, decreased branching dendrites and decreased dendrite length compared with wild-type cells
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• impaired BDNF-induced excitatory postsynaptic current potentiation
• however, mice exhibit normal excitatory postsynaptic current amplitude and paired-pulse potentiation
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cardiovascular system
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• poorly vascularized brains corresponding to regions of increased apoptosis
• abnormal vascular patterning and larger vessel diameter at E16.5 and E18.5
• glomeruloid terminal structures form in the subventricular zone
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• dilated and congested atria at E18.5
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• at E18.5
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• vacuolated and disorganized wall
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hemorrhage
(
J:203073
)
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• in the brain
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growth/size/body
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• at E18
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vision/eye
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• increased at E15.5 and E16.5
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cellular
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• at E13.5 in the dorsal root ganglion at the thoracic and lumbar levels affecting all neuronal subtypes
• at E14.5 in vestibular and glossopharyngeal ganglia
• at E15.5 and E16.5 in the ventral neuroepithelium, retina, thalamus and cortex
• at E18.5 in the neuroepithelium, subventricular zone, cingulum and dorsal subiculum of the hippocampus, cortex, caudate putamen, ventroposterolateral and medial thalamic nuclei and nucleus reuniens
• more severe during development
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• increased at E15.5 and E16.5
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• hippocampal nerves exhibit altered response to BDNF with increased axonal length, number of dendrites, decreased branching dendrites and decreased dendrite length compared with wild-type cells
• however, axonal growth in response to BDNF is normal
|
