All Phenotypes Gt(ROSA)26Sor<tm1(CAG-Etv2,-GFP)Hkata> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}
targeted mutation 1, Hiroshi Kataoka
MGI:5527402

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5527433
cn2	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Sox17^{tm1(icre)Heli}/Sox17⁺	involves: 129S2/SvPas * C57BL/6NCrlj * CBA/JNCrlj	MGI:5527438
cn3	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:5527434
cn4	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	MGI:5527435
cn5	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Meox1^tm1(cre)Jpa/Meox1⁺	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5527436
cn6	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Sox1^tm1(cre)Take/Sox1⁺	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5527437

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata} mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203163 )

• mice are healthy and fertile without any obvious phenotypes

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Sox17^{tm1(icre)Heli}/Sox17⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata} mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)
Sox17^{tm1(icre)Heli} mutation (0 available); any Sox17 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203163 )

N	• mice are obtained in normal Mendelian ratios

embryo

embryo phenotype ( J:203163 )

N	• mice develop without phenotypic abnormalities during embryogenesis

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:203163 )

• most mice die around E11.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:203163 )

• dilated at E10.5 to E11.5

• fragile blood vesels

hemorrhage ( J:203163 )

• bleeding in some mice at E10.5 to E11.5

hematopoietic system

abnormal definitive hematopoiesis ( J:203163 )

• abnormal hematopoiesis that biases the developmental program towards endothelial cells

embryo

abnormal vitelline vasculature morphology ( J:203163 )

• dilated at E10.5 to E11.5

• fragile blood vesels

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata} mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:203163 )

• fewer than expected mice are observed at P10

hematopoietic system

abnormal hematopoietic system morphology/development ( J:203163 )

• disturbed hematopoietic development in adult hematopoietic progenitor cells

anemia ( J:203163 )

• severe in some mice

abnormal bone marrow cell morphology/development ( J:203163 )

• reduced total number of colony forming units from bone marrow cells

decreased common myeloid progenitor cell number ( J:203163 )

• in bone marrow cells

decreased erythroid progenitor cell number ( J:203163 )

• in bone marrow cells

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Meox1^tm1(cre)Jpa/Meox1⁺
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata} mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)
Meox1^tm1(cre)Jpa mutation (0 available); any Meox1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203163 )

• mice exhibit no obvious phenotype and normal vasculature at E11.5

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺ Sox1^tm1(cre)Take/Sox1⁺
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata} mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)
Sox1^tm1(cre)Take mutation (1 available); any Sox1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203163 )

N	• mice are obtained in normal Mendelian ratios

cardiovascular system

cardiovascular system phenotype ( J:203163 )

N	• at E10.5, mice exhibit no enhancement of endothelial cells

hematopoietic system

hematopoietic system phenotype ( J:203163 )

N	• at E10.5, mice exhibit no enhancement of hematopoietic progenitor cells

embryo

embryo phenotype ( J:203163 )

N	• mice develop without phenotypic abnormalities during embryogenesis

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