Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}
• Allele Name: targeted mutation 1, Hiroshi Kataoka
• Allele ID: MGI:5527402
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5527433
cn2	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^+ Sox17^tm1(icre)Heli/Sox17^+	involves: 129S2/SvPas * C57BL/6NCrlj * CBA/JNCrlj	MGI:5527438
cn3	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^+ Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:5527434
cn4	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	MGI:5527435
cn5	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^+ Meox1^tm1(cre)Jpa/Meox1^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5527436
cn6	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^+ Sox1^tm1(cre)Take/Sox1^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5527437

Genotype
MGI:5527433

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203163 )

• mice are healthy and fertile without any obvious phenotypes

Genotype
MGI:5527438

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺; Sox17^{tm1(icre)Heli}/Sox17⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

mortality/aging ( J:203163 )

N • mice are obtained in normal Mendelian ratios

embryo

embryo phenotype ( J:203163 )

N • mice develop without phenotypic abnormalities during embryogenesis

Genotype
MGI:5527434

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:203163 )

• most mice die around E11.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:203163 )

• dilated at E10.5 to E11.5

• fragile blood vesels

hemorrhage ( J:203163 )

• bleeding in some mice at E10.5 to E11.5

hematopoietic system

abnormal definitive hematopoiesis ( J:203163 )

• abnormal hematopoiesis that biases the developmental program towards endothelial cells

embryo

abnormal vitelline vasculature morphology ( J:203163 )

• dilated at E10.5 to E11.5

• fragile blood vesels

Genotype
MGI:5527435

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

mortality/aging

preweaning lethality, incomplete penetrance ( J:203163 )

• fewer than expected mice are observed at P10

hematopoietic system

abnormal hematopoietic system morphology/development ( J:203163 )

• disturbed hematopoietic development in adult hematopoietic progenitor cells

anemia ( J:203163 )

• severe in some mice

abnormal bone marrow cell morphology/development ( J:203163 )

• reduced total number of colony forming units from bone marrow cells

decreased common myeloid progenitor cell number ( J:203163 )

• in bone marrow cells

decreased erythroid progenitor cell number ( J:203163 )

• in bone marrow cells

Genotype
MGI:5527436

cn5

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺; Meox1^tm1(cre)Jpa/Meox1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

normal phenotype

no abnormal phenotype detected ( J:203163 )

• mice exhibit no obvious phenotype and normal vasculature at E11.5

Genotype
MGI:5527437

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺; Sox1^tm1(cre)Take/Sox1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

mortality/aging ( J:203163 )

N • mice are obtained in normal Mendelian ratios

cardiovascular system

cardiovascular system phenotype ( J:203163 )

N • at E10.5, mice exhibit no enhancement of endothelial cells

hematopoietic system

hematopoietic system phenotype ( J:203163 )

N • at E10.5, mice exhibit no enhancement of hematopoietic progenitor cells

embryo

embryo phenotype ( J:203163 )

N • mice develop without phenotypic abnormalities during embryogenesis