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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
targeted mutation 1, Darren Moore
MGI:5527542
Summary 2 genotypes


Genotype
MGI:5527550
hm1
Allelic
Composition		 Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Genetic
Background		 B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:101977 )
• homozygotes are viable and fertile




Genotype
MGI:5750683
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Tg(Slc6a3-icre)1Fto/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Slc6a3-icre)1Fto mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:218456 )
N
• mice do not exhibit abnormalities in the distribution or levels of alpha-synuclein, ubiquitin, tau, glial markers, or autophagy markers or neuronal degeneration in the brain
abnormal dopaminergic neuron morphology ( J:218456 )
• cultured midbrain dopaminergic neurons exhibit an increase in neurite complexity
• dopaminergic neurons from 20-22 month old, but not 5 month old mice, exhibit abnormal nuclei with reduced nuclear circularity
• substantia nigra pars compacta neuronal nuclei exhibit irregular shape and numerous invaginations of the nuclear envelope
• however, mice do not exhibit nigral dopaminergic neuronal loss and have normal dopaminergic nerve terminals in the striatum

behavior/neurological
behavior/neurological phenotype ( J:218456 )
N
• mice exhibit normal motor behaviors in the open field and on the rotarod and normal gait

taste/olfaction
taste/olfaction phenotype ( J:218456 )
N
• mice exhibit normal olfactory function




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory