Phenotypes associated with this allele

• Allele Symbol: Flot2^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:5527543
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flot2^tm1Mak/Flot2^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5527554
cx2	Flot2^tm1Mak/Flot2^tm1Mak Tg(MMTV-PyVT)634Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5527556

Genotype
MGI:5527554

hm1

• Allelic Composition: Flot2^tm1Mak/Flot2^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:203238 )

• mouse embryonic fibroblasts fail to form functional flotilin

• however, caveolar membrane microdomains form

Genotype
MGI:5527556

cx2

• Allelic Composition: Flot2^tm1Mak/Flot2^tm1Mak; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

mortality/aging

premature death ( J:203238 )

• as in Tg(MMTV-PyVT)634Mul mice

neoplasm

increased mammary gland tumor incidence ( J:203238 )

• as in Tg(MMTV-PyVT)634Mul mice

decreased metastatic potential ( J:203238 )

• 10-fold fewer visible macro-metastases in the lungs compared to in Tg(MMTV-PyVT)634Mul mice

• fewer micro-metastases in the lungs compared to in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:203238 )

• as in Tg(MMTV-PyVT)634Mul mice

integument

increased mammary gland tumor incidence ( J:203238 )

• as in Tg(MMTV-PyVT)634Mul mice