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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapkapk2tm1.1Yaff
targeted mutation 1.1, Michael Yaffe
MGI:5528531
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff involves: 129S4/SvJae * C57BL/6 MGI:5528650
cn2
 		Krastm4Tyj/Kras+
Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Trp53tm1Brn/Trp53tm1Brn 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5528686
cn3
 		Krastm4Tyj/Kras+
Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff 		involves: 129S4/SvJae * C57BL/6 MGI:5528687


Genotype
MGI:5528650
hm1
Allelic
Composition		 Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2tm1.1Yaff mutation (1 available); any Mapkapk2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:203686 )
• homozygotes are viable and fertile




Genotype
MGI:5528686
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (83 available)
Mapkapk2tm1.1Yaff mutation (1 available); any Mapkapk2 mutation (35 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (235 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:203686 )
• lung adenocarcinomas cover 11% of lung area 6 weeks after administration of a Cre-recombinase expressing adenovirus
• tumor burden progresses from 11% of lung (6 weeks) to 45% at experimental endpoint (12+ weeks) in the presence of a Cre-recombinase expressing adenovirus
• Mapkap2 expressing tumors (MK2+) represent a higher proportion of tumor burden, however over time the proportion of these tumors decreases and the proportion of Mapkapk2 (MK2-) null tumors increases in the presence of a Cre-recombinase expressing adenovirus
• proportion of total lung tumor burden composed of Mapkapk2 (MK2-) null tumors is reduced from 39% to 11% following cisplatin treatment

respiratory system
increased lung adenoma incidence ( J:203686 )
• lung adenocarcinomas cover 11% of lung area 6 weeks after administration of a Cre-recombinase expressing adenovirus
• tumor burden progresses from 11% of lung (6 weeks) to 45% at experimental endpoint (12+ weeks) in the presence of a Cre-recombinase expressing adenovirus
• Mapkap2 expressing tumors (MK2+) represent a higher proportion of tumor burden, however over time the proportion of these tumors decreases and the proportion of Mapkapk2 (MK2-) null tumors increases in the presence of a Cre-recombinase expressing adenovirus
• proportion of total lung tumor burden composed of Mapkapk2 (MK2-) null tumors is reduced from 39% to 11% following cisplatin treatment




Genotype
MGI:5528687
cn3
Allelic
Composition		 Krastm4Tyj/Kras+
Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (83 available)
Mapkapk2tm1.1Yaff mutation (1 available); any Mapkapk2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:203686 )
• lung adenocarcinomas cover 9% of lung area 9 weeks after administration of a Cre-recombinase expressing adenovirus
• tumor burden progresses from 9% of lung (6 weeks) to 28% at experimental endpoint (12+ weeks) in the presence of a Cre-recombinase expressing adenovirus
• Mapkap2 expressing tumors (MK2+) represent a higher proportion of tumor burden in relation to Mapkapk2 (MK2-) null tumors in the presence of a Cre-recombinase expressing adenovirus adenovirus

respiratory system
increased lung adenoma incidence ( J:203686 )
• lung adenocarcinomas cover 9% of lung area 9 weeks after administration of a Cre-recombinase expressing adenovirus
• tumor burden progresses from 9% of lung (6 weeks) to 28% at experimental endpoint (12+ weeks) in the presence of a Cre-recombinase expressing adenovirus
• Mapkap2 expressing tumors (MK2+) represent a higher proportion of tumor burden in relation to Mapkapk2 (MK2-) null tumors in the presence of a Cre-recombinase expressing adenovirus adenovirus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory