Phenotypes associated with this allele

• Allele Symbol: Cacna1c^tm1.1Wac
• Allele Name: targeted mutation 1.1, William A Catterall
• Allele ID: MGI:5528791
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1c^tm1.1Wac/Cacna1c^tm1.1Wac	involves: C57BL/6	MGI:5528794

Genotype
MGI:5528794

hm1

• Allelic Composition: Cacna1c^tm1.1Wac/Cacna1c^tm1.1Wac
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:203057 )

N • fertile

cardiovascular system

increased myocardial fiber size ( J:203057 )

cardiac hypertrophy ( J:203057 )

abnormal cardiac muscle contractility ( J:203057 )

• ~20% of dissociated myocytes fail to sustain contractions during stimulation at 1Hz greater proportion of cells exhibiting arrhythmic contractions independent from frequency of stimulation

decreased cardiac muscle contractility ( J:203057 )

• marked decrease in the increase in cell shortening induced by Iso treatment in isolated myocytes

abnormal myocardial fiber physiology ( J:203057 )

• basal and PKA regulation of Cav1.2 channels in neonatal ventricular myocytes are impaired

• ~20% of dissociated myocytes fail to sustain contractions during stimulation at 1Hz greater proportion of cells exhibiting arrhythmic contractions independent from frequency of stimulation

muscle

increased myocardial fiber size ( J:203057 )

abnormal cardiac muscle contractility ( J:203057 )

• ~20% of dissociated myocytes fail to sustain contractions during stimulation at 1Hz greater proportion of cells exhibiting arrhythmic contractions independent from frequency of stimulation

decreased cardiac muscle contractility ( J:203057 )

• marked decrease in the increase in cell shortening induced by Iso treatment in isolated myocytes

abnormal muscle electrophysiology ( J:203057 )

• in neonatal ventricular myocytes and adult cardiomyocytes basal L-type currents are reduced and increase in Iso-stimulated Ca2+ currents is impaired

behavior/neurological

decreased aerobic running capacity ( J:203057 )

• shorter total running distance before exhaustion

homeostasis/metabolism

decreased aerobic running capacity ( J:203057 )

• shorter total running distance before exhaustion

growth/size/body

cardiac hypertrophy ( J:203057 )