Phenotypes associated with this allele

• Allele Symbol: Clec4d^tm1.1Shoy
• Allele Name: targeted mutation 1.1, Sho Yamasaki
• Allele ID: MGI:5528858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4d^tm1.1Shoy/Clec4d^tm1.1Shoy	involves: 129P2/OlaHsd * C57BL/6	MGI:5528880

Genotype
MGI:5528880

hm1

• Allelic Composition: Clec4d^tm1.1Shoy/Clec4d^tm1.1Shoy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:203159 )

• in mice treated with oil-in-water emulsion of trehalose-6,60'-dimycolate (TDM)

immune system

abnormal thymus morphology ( J:203159 )

• mice exhibit impaired TDM-induced thymic atrophy compared with wild-type mice

decreased dendritic cell number ( J:203159 )

• TDM-treated mice exhibit less of an increase in draining lymph nodes dendritic cells compared with wild-type mice

abnormal immune system physiology ( J:203159 )

decreased susceptibility to type IV hypersensitivity reaction ( J:203159 )

• TDM-treated mice immunized with ovalbumin exhibit reduced footpad swelling and anti-ovalbumin IgG compared with wild-type mice

abnormal antigen presentation ( J:203159 )

• impaired antigen presenting cell function

abnormal immune serum protein physiology ( J:203159 )

decreased IgG level ( J:203159 )

• in TDM-treated mice immunized with ovalbumin

decreased circulating interleukin-17 level ( J:203159 )

• in mice re-challenged with MOG antigen and pertussis toxin 20 days after immunization for EAE

abnormal chemokine secretion ( J:203159 )

• bone marrow-derived dendritic cells and macrophages stimulated with platelets coated in trehalose-6,60'-dimycolate (TDM) or zymosan exhibit reduced MIP-2 secretion compared with wild-type cells

abnormal interferon-gamma secretion ( J:203159 )

• TDM-treated bone marrow dendritic cells co-cultured with OT-II cells and OVA323-339 or OVA257-264 peptide or ovalbumin protein exhibit less of an increase in IFN-gamma and IL17 compared with wild-type cells

abnormal interleukin-17 secretion ( J:203159 )

• TDM-treated bone marrow dendritic cells co-cultured with OT-II cells and OVA323-339 peptide exhibit less of an increase in IFN-gamma and IL17 compared with wild-type cells

decreased tumor necrosis factor secretion ( J:203159 )

• in bone marrow-derived dendritic cells and macrophages stimulated with platelets coated in TDM or zymosan

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:203159 )

• almost completely abrogated with reduced skin inflammation in TDM-treated mice

granulomatous inflammation ( J:203159 )

• in mice treated with TDM but not as severe as in wild-type mice

lung inflammation ( J:203159 )

• in mice treated with TDM but not as severe as in wild-type mice

abnormal response to infection ( J:203159 )

• mice infected with Mycobacterium bovis BCG exhibit reduced IFN-gamma production in response to PPD compared with wild-type mice

respiratory system

lung inflammation ( J:203159 )

• in mice treated with TDM but not as severe as in wild-type mice

homeostasis/metabolism

decreased circulating interleukin-17 level ( J:203159 )

• in mice re-challenged with MOG antigen and pertussis toxin 20 days after immunization for EAE

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:203159 )

• in mice treated with oil-in-water emulsion of trehalose-6,60'-dimycolate (TDM)

decreased physiological sensitivity to xenobiotic ( J:203159 )

• mice treated with TDM exhibit reduced lung inflammation, granuloma area and lethality compared with wild-type mice

hematopoietic system

abnormal thymus morphology ( J:203159 )

• mice exhibit impaired TDM-induced thymic atrophy compared with wild-type mice

decreased dendritic cell number ( J:203159 )

• TDM-treated mice exhibit less of an increase in draining lymph nodes dendritic cells compared with wild-type mice

decreased IgG level ( J:203159 )

• in TDM-treated mice immunized with ovalbumin

endocrine/exocrine glands

abnormal thymus morphology ( J:203159 )

• mice exhibit impaired TDM-induced thymic atrophy compared with wild-type mice