About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc14tm1.1Flv
targeted mutation 1.1, Richard A Flavell
MGI:5528987
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mirc14tm1.1Flv/Mirc14tm1.1Flv
Ptentm1Hwu/Ptentm1Hwu
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA/2 * SJL MGI:5529025
cn2
 		Mirc14tm1.1Flv/Mirc14tm1.1Flv
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6N * DBA/2 * SJL MGI:5529019


Genotype
MGI:5529025
cn1
Allelic
Composition		 Mirc14tm1.1Flv/Mirc14tm1.1Flv
Ptentm1Hwu/Ptentm1Hwu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.1Flv mutation (0 available); any Mirc14 mutation (1 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:203157 )
N
• NKT cell development is rescued




Genotype
MGI:5529019
cn2
Allelic
Composition		 Mirc14tm1.1Flv/Mirc14tm1.1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.1Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory