About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc14tm1.2Flv
targeted mutation 1.2, Richard A Flavell
MGI:5528993
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529020
cx2
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Mirc14tm1.2Flv/Mirc14tm1.2Flv 		involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529023
cx3
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(LCKprBCL2L1)12Sjk/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529021
cx4
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(Cd4-TcraDN32D3)1Aben/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529024
cx5
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529026
cx6
 		Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv
Mirc16tm1.2Flv/Mirc16tm1.2Flv 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5529028


Genotype
MGI:5529020
hm1
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:203157 )
• in bone marrow chimeras reconstitution experiments whether reconstituted with Mirc14-deficient or wild-type bone marrow
abnormal T cell receptor V(D)J recombination ( J:203157 )
• Jalpha gene usage is biased in favor of proximal versus distal segments
decreased double-positive T cell number ( J:203157 )
• in dexmethasone-treated mice
decreased B cell number ( J:203157 )
• in the bone marrow
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal T cell physiology ( J:203157 )
• thymocytes exhibit reduced extracellular acidification rate indicating decreased glycolysis compared with wild-type cells
• however, thymocytes exhibit normal oxygen consumption, mitochondrial mass, and mitochondrial reactive oxygen species production
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

cellular
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

hematopoietic system
abnormal T cell differentiation ( J:203157 )
• in bone marrow chimeras reconstitution experiments whether reconstituted with Mirc14-deficient or wild-type bone marrow
abnormal T cell receptor V(D)J recombination ( J:203157 )
• Jalpha gene usage is biased in favor of proximal versus distal segments
decreased double-positive T cell number ( J:203157 )
• in dexmethasone-treated mice
decreased B cell number ( J:203157 )
• in the bone marrow
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal T cell physiology ( J:203157 )
• thymocytes exhibit reduced extracellular acidification rate indicating decreased glycolysis compared with wild-type cells
• however, thymocytes exhibit normal oxygen consumption, mitochondrial mass, and mitochondrial reactive oxygen species production
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice




Genotype
MGI:5529023
cx2
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Mirc14tm1.2Flv/Mirc14tm1.2Flv
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




Genotype
MGI:5529021
cx3
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer

immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer




Genotype
MGI:5529024
cx4
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Tg(Cd4-TcraDN32D3)1Aben/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Tg(Cd4-TcraDN32D3)1Aben mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal NK T cell physiology ( J:203157 )
• decreased proliferation of developing NKT cells

hematopoietic system
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal NK T cell physiology ( J:203157 )
• decreased proliferation of developing NKT cells




Genotype
MGI:5529026
cx5
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Mirc15tm1.2Flv mutation (0 available); any Mirc15 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
decreased B cell number ( J:203157 )
• in the bone marrow

growth/size/body
decreased body weight ( J:203157 )

hematopoietic system
decreased B cell number ( J:203157 )
• in the bone marrow




Genotype
MGI:5529028
cx6
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Mirc15tm1.2Flv/Mirc15tm1.2Flv
Mirc16tm1.2Flv/Mirc16tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
Mirc15tm1.2Flv mutation (0 available); any Mirc15 mutation (2 available)
Mirc16tm1.2Flv mutation (0 available); any Mirc16 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:203157 )
• mice have yet to be obtained indicating incompatibility with life




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory