All Phenotypes Mpp3<tm1.1Wij> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mpp3^tm1.1Wij
targeted mutation 1.1, Jan Wijnholds
MGI:5529041

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Emx1^tm1(cre)Ito/Emx1⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5529700
cn2	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Tg(rx3-icre)1Mjam/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N	MGI:5529776
cn3	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL	MGI:5529777
cn4	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 Tg(RNU6-RNAi:Mpp5)13Wij/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL	MGI:5529778

Allelic Composition	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Emx1^tm1(cre)Ito/Emx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Mpp3^tm1.1Wij mutation (0 available); any Mpp3 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal migration ( J:198427 )

• adverse affect on neuron migration

abnormal cerebral cortex morphology ( J:198427 )

• mild cellular disorganization in the ventricular zone of the cortex at E12.5

• becoming more extreme at E16.5

• normal cellular organization at the level of the 3rd ventricle where cre is not expressed

• cortex thickness and lamination are normal at E16.5

cellular

abnormal mitotic spindle morphology ( J:198427 )

• spindle orientation in cortical progenitor cells tends to shift from horizontal to oblique

• vertical spindle orientation is normal

increased mitotic index ( J:198427 )

• increased number of mitotic cells in cortex with basal location rather than apical location

• apically located proliferating cells are also increased

• increased number of mitotic cells in cortex over all

abnormal neuronal migration ( J:198427 )

• adverse affect on neuron migration

Allelic Composition	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Tg(rx3-icre)1Mjam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpp3^tm1.1Wij mutation (0 available); any Mpp3 mutation (44 available)
Tg(rx3-icre)1Mjam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:199562 )

• no histological abnormalities at 2 months of age

abnormal retina outer plexiform layer morphology ( J:199562 )

• occasional ingression of photoreceptors at 2 months

abnormal retina outer limiting membrane morphology ( J:199562 )

• defects observed at 6 months along with vascular abnormalities

• occasional ectopic photo receptors between the outer limiting membrane and the retinal pigment epithelium

• thinning of outer limiting membrane and integrity disrupted at 6 and 12 months

• 6 month old mice exposed to 3000 lux white light for 72 hours develop foci of cells in the space between the outer limiting membrane and the retinal pigment layer

• integrity of outer limiting membrane is disrupted in 6 month old mice by exposure to 3000 lux white light for 72 hours

increased susceptibility to age-related retinal degeneration ( J:199562 )

• occasional retinal degeneration and rosettes at 3 months of age

• degeneration detected at 6 months of age

• morphological defects are more distinct at 12 months

retina degeneration ( J:199562 )

• increased in 6 month old mice exposed to 3000 lux white light for 72 hours

• massive gliosis when exposed to light

abnormal electroretinogram waveform feature ( J:199562 )

• both scotopic and photopic retinography varies from normal to mildly subnormal depending on the extent of morphological abnormalities

Allelic Composition	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpp3^tm1.1Wij mutation (0 available); any Mpp3 mutation (44 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:199562 )

• phenotype similar to that when Tg(rx3-icre)1Mjam was used for cre expression

abnormal retina outer nuclear layer morphology ( J:199562 )

• sporadic loss of photoreceptors at 18 months

abnormal retina outer limiting membrane morphology ( J:199562 )

• areas of disruption and ectopic photoreceptors at 18 months

• slight thinning of layer at 6, 12, 18 months

abnormal electroretinogram waveform feature ( J:199562 )

• phenotype similar to that when Tg(rx3-icre)1Mjam was used for cre expression

Allelic Composition	Mpp3^tm1.1Wij/Mpp3^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 Tg(RNU6-RNAi:Mpp5)13Wij/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpp3^tm1.1Wij mutation (0 available); any Mpp3 mutation (44 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
Tg(RNU6-RNAi:Mpp5)13Wij mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:199562 )

• four fold increase in degenerative spots on retinas compared to controls

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