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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb1tm14.1Ref
targeted mutation 14.1, Reinhard Fassler
MGI:5529145
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgb1tm14.1Ref/Itgb1tm14.1Ref Not Specified MGI:5529150
ht2
 		Itgb1tm14.1Ref/Itgb1tm15.1Ref Not Specified MGI:5529165
cn3
 		Itgb1tm1Ref/Itgb1tm14.1Ref
Tg(KRT5-cre)5132Jlj/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J MGI:5529164


Genotype
MGI:5529150
hm1
Allelic
Composition		 Itgb1tm14.1Ref/Itgb1tm14.1Ref
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm14.1Ref mutation (0 available); any Itgb1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:185558 )
• no offspring are produced from breeding heterozygotes
embryonic lethality, complete penetrance ( J:203018 )
• peri-implantation lethality indicated by severe malformations at E7.5

cellular
abnormal cell physiology ( J:203018 )
• ES cells adhere less to feeder cells compared with wild-type cells




Genotype
MGI:5529165
ht2
Allelic
Composition		 Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm14.1Ref mutation (0 available); any Itgb1 mutation (60 available)
Itgb1tm15.1Ref mutation (0 available); any Itgb1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:203018 )
• peri-implantation lethality indicated by severe malformations at E7.5

cellular
abnormal cell physiology ( J:203018 )
• ES cells adhere less to feeder cells compared with wild-type cells




Genotype
MGI:5529164
cn3
Allelic
Composition		 Itgb1tm1Ref/Itgb1tm14.1Ref
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm14.1Ref mutation (0 available); any Itgb1 mutation (60 available)
Itgb1tm1Ref mutation (0 available); any Itgb1 mutation (60 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:203018 )
N
• mice exhibit normal follicle morphogenesis and keratinocyte spreading and proliferation
abnormal hair growth ( J:203018 )
• patchy hair loss over the dorsal midline of the skull
abnormal epidermal layer morphology ( J:203018 )
• less affected than in Itgb1tm1Ref/Itgb1tm1Ref Tg(KRT1-5-cre)5132Jlj mice
• however, no subepidermal blistering is observed

homeostasis/metabolism
delayed wound healing ( J:203018 )
• in a scratch wounding assay

cellular




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory