All Phenotypes Itgb1<tm15.1Ref> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itgb1^tm15.1Ref
targeted mutation 15.1, Reinhard Fassler
MGI:5529154

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb1^tm15.1Ref/Itgb1^tm15.1Ref	Not Specified	MGI:5529162
ht2	Itgb1^tm14.1Ref/Itgb1^tm15.1Ref	Not Specified	MGI:5529165
cn3	Itgb1^tm1Ref/Itgb1^tm15.1Ref Tg(KRT5-cre)5132Jlj/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J	MGI:5529163

Allelic Composition	Itgb1^tm15.1Ref/Itgb1^tm15.1Ref
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm15.1Ref mutation (0 available); any Itgb1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:203018 )

• peri-implantation lethality indicated by severe malformations at E7.5

cellular

abnormal cell physiology ( J:203018 )

• ES cells adhere less to feeder cells compared with wild-type cells

Allelic Composition	Itgb1^tm14.1Ref/Itgb1^tm15.1Ref
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm14.1Ref mutation (0 available); any Itgb1 mutation (60 available)
Itgb1^tm15.1Ref mutation (0 available); any Itgb1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:203018 )

• peri-implantation lethality indicated by severe malformations at E7.5

cellular

abnormal cell physiology ( J:203018 )

• ES cells adhere less to feeder cells compared with wild-type cells

Allelic Composition	Itgb1^tm1Ref/Itgb1^tm15.1Ref Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm15.1Ref mutation (0 available); any Itgb1 mutation (60 available)
Itgb1^tm1Ref mutation (0 available); any Itgb1 mutation (60 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased keratinocyte adhesion ( J:203018 )

• defective adhesion and more pronounced spreading

decreased keratinocyte proliferation ( J:203018 )

• cells do not grow into a confluent monolayer and undergo rapidly initiated terminal differentiation

abnormal hair growth ( J:203018 )

• patchy hair loss over the dorsal midline of the skull

enlarged hair follicles ( J:203018 )

• intermixed with normal follicles

abnormal epidermal layer morphology ( J:203018 )

• less affected than in Itgb1^tm1Ref/Itgb1^tm1Ref Tg(KRT1-5-cre)5132Jlj mice

• however, no subepidermal blistering is observed

cellular

decreased keratinocyte adhesion ( J:203018 )

• defective adhesion and more pronounced spreading

decreased keratinocyte proliferation ( J:203018 )

• cells do not grow into a confluent monolayer and undergo rapidly initiated terminal differentiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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