Phenotypes associated with this allele

• Allele Symbol: Sod1^tm1Svb
• Allele Name: targeted mutation 1, Susan V Brooks
• Allele ID: MGI:5529176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sod1^tm1Svb/Sod1^tm1Svb Tg(ACTA1-cre)79Jme/0	involves: C57BL/6J * SJL	MGI:5529251

Genotype
MGI:5529251

cn1

• Allelic Composition: Sod1^tm1Svb/Sod1^tm1Svb; Tg(ACTA1-cre)79Jme/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:201098 )

N • mice do not exhibit functional denervation

N • muscles exhibit normal mitochondrial function, reactive oxygen species generation, redox status and heat-shock response

increased extensor digitorum longus weight ( J:201098 )

• at 16 to 17 months

increased quadriceps weight ( J:201098 )

• at 16 to 17 months

increased gastrocnemius weight ( J:201098 )

• at 6 months and 16 to 17 months

increased soleus weight ( J:201098 )

• at 16 to 17 months

increased tibialis anterior weight ( J:201098 )

• at 16 to 17 months

centrally nucleated skeletal muscle fibers ( J:201098 )

• remains constant throughout life

increased skeletal muscle mass ( J:201098 )

• for a variety of muscles at 6 months and 16 to 17 months

abnormal muscle physiology ( J:201098 )

• ongoing, focal degeneration-regeneration

abnormal muscle regeneration ( J:201098 )

• ongoing, focal degeneration-regeneration

muscle weakness ( J:201098 )

behavior/neurological

behavior/neurological phenotype ( J:201098 )

N • mice exhibit normal performance on a rotarod

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:201098 )

N • mice exhibit normal performance on a treadmill

nervous system

nervous system phenotype ( J:201098 )

N • mice do not exhibit functional denervation

limbs/digits/tail

increased extensor digitorum longus weight ( J:201098 )

• at 16 to 17 months

increased quadriceps weight ( J:201098 )

• at 16 to 17 months

increased gastrocnemius weight ( J:201098 )

• at 6 months and 16 to 17 months

increased soleus weight ( J:201098 )

• at 16 to 17 months

increased tibialis anterior weight ( J:201098 )

• at 16 to 17 months