Phenotypes associated with this allele

• Allele Symbol: Chad^tm1Gast
• Allele Name: targeted mutation 1, Gunhild A Stordalen
• Allele ID: MGI:5529270
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chad^tm1Gast/Chad^tm1Gast	B6.129-Chad^tm1Gast	MGI:5529272

Genotype
MGI:5529272

hm1

• Allelic Composition: Chad^tm1Gast/Chad^tm1Gast
• Genetic Background: B6.129-Chad^tm1Gast

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone epiphyseal plate proliferative zone ( J:203141 )

• increased at 3 and 6 weeks

increased long bone epiphyseal plate size ( J:203141 )

• at 3 weeks despite normal femur length with increased proliferating and resting zones

decreased bone mineral density ( J:203141 )

♂ • at 6 weeks in male mice

abnormal compact bone morphology ( J:203141 )

♂ • male mice exhibit lower polar moment of inertia and cortical diameter at the midshaft compared with wild-type mice

abnormal trabecular bone morphology ( J:203141 )

♀ • female mice exhibit decreased trabecular spacing compared with wild-type mice

increased trabecular bone thickness ( J:203141 )

• at 4 months with increased structural model index

decreased bone strength ( J:203141 )

• lower femoral neck failure load and tibial strength at 4, but not 8, months

adipose tissue

decreased total body fat amount ( J:203141 )

♂ • at 6 weeks in male mice