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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clec4ftm1Ymed
targeted mutation 1, Yang-Ming University Institute of Clinical Medicine
MGI:5529277
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clec4ftm1Ymed/Clec4ftm1Ymed B6.129S7-Clec4ftm1Ymed MGI:5529327


Genotype
MGI:5529327
hm1
Allelic
Composition		 Clec4ftm1Ymed/Clec4ftm1Ymed
Genetic
Background		 B6.129S7-Clec4ftm1Ymed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec4ftm1Ymed mutation (0 available); any Clec4f mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:203199 )
N
• mice exhibit normal susceptibility to L. monocytogenes infection
abnormal macrophage cytokine production ( J:203199 )
• Kupffer cells stimulated with alpha-GalCer produce less IFN-gamma compared with wild-type mice
• however, stimulated mice produce normal amounts of IL4
decreased interferon-gamma secretion ( J:203199 )
• from Kupffer cells stimulated with alpha-GalCer
• however, suppression using a blocking antibody against Cd1d1 is normal

hematopoietic system
abnormal macrophage cytokine production ( J:203199 )
• Kupffer cells stimulated with alpha-GalCer produce less IFN-gamma compared with wild-type mice
• however, stimulated mice produce normal amounts of IL4




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory