Phenotypes associated with this allele

• Allele Symbol: Mecp2^tm4.1Bird
• Allele Name: targeted mutation 4.1, Adrian Bird
• Allele ID: MGI:5529361
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm4.1Bird/Mecp2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5529466
ot2	Mecp2^tm4.1Bird/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:5702941

Genotype
MGI:5529466

ht1

• Allelic Composition: Mecp2^tm4.1Bird/Mecp2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

♀ • females exhibit milder motor coordination and behavioral phenotypes than males

Genotype
MGI:5702941

ot2

• Allelic Composition: Mecp2^tm4.1Bird/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal behavior ( J:227401 )

♂ • motor coordination and behavioral phenotypes are more severe than in mice carrying Mecp^tm5.1Brd and Mecp^tm6.1Brd

♂ • onset of phenotypes is more rapid than observed in mice carrying Mecp^tm5.1Brd and Mecp^tm6.1Brd

abnormal motor learning ( J:227401 )

♂ • decrease in latency to fall in 3-day accelerated rotarod-learning paradigm by day 3 as compared to controls

decreased anxiety-related response ( J:227401 )

♂ • increased time in open arms of elevated plus maze as compared to controls

abnormal motor capabilities/coordination/movement ( J:227401 )

♂ • increase in latency to fall in hanging wire test as compared to wild-type litter mates, but not as compared to Mecp^tm3.1Brd (WT-GFP) control

growth/size/body

decreased body weight ( J:227401 )

♂

mortality/aging

premature death ( J:227401 )

♂ • median survival 13 week

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:227401