Phenotypes associated with this allele

• Allele Symbol: Mecp2^tm5.1Bird
• Allele Name: targeted mutation 5.1, Adrian Bird
• Allele ID: MGI:5529365
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm5.1Bird/Mecp2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5529467
ot2	Mecp2^tm5.1Bird/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:5702951

Genotype
MGI:5529467

ht1

• Allelic Composition: Mecp2^tm5.1Bird/Mecp2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:227401 )

♀ • females exhibit milder motor coordination and behavioral phenotypes than males

Genotype
MGI:5702951

ot2

• Allelic Composition: Mecp2^tm5.1Bird/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal behavior ( J:227401 )

♂ • motor coordination and behavioral phenotypes are intermediate to phenotypes observed in mice carrying Mecp^tm4.1Brd and Mecp^tm6.1Brd

♂ • onset of phenotypes is initially rapid and then stable until 33 weeks as compared to mice carrying Mecp^tm4.1Brd and Mecp^tm6.1Brd

decreased anxiety-related response ( J:227401 )

♂ • increased time in open arms of elevated plus maze as compared to controls

abnormal motor capabilities/coordination/movement ( J:227401 )

♂ • increase in latency to fall in hanging wire test as compared to controls

growth/size/body

decreased body weight ( J:227401 )

♂

mortality/aging

premature death ( J:227401 )

♂ • median survival is 30 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:227401