Phenotypes associated with this allele

• Allele Symbol: Tg(Sirt1)ASrn
• Allele Name: transgene insertion A, Manuel Serrano
• Allele ID: MGI:5529482
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Sirt1)ASrn/?	involves: C57BL/6 * CBA	MGI:5529491

Genotype
MGI:5529491

tg1

• Allelic Composition: Tg(Sirt1)ASrn/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased food intake ( J:137868 )

• increased food intake on high fat diet as compared to wild type control

homeostasis/metabolism

increased energy expenditure ( J:137868 )

• increased energy expenditure on high fat diet as compared to wild type control

improved glucose tolerance ( J:137868 )

• improved glucose tolerance after 7 weeks on high fat diet as measured by area-under-the-curve values as compared to controls

• blood glucose levels in transgenic mice fed high fat diet decrease more rapidly than controls following administration of IP glucose

• blood glucose levels in transgenic mice fed high fat diet do not increase as much as controls following pyruvate tolerance test (PTT)

immune system

increased susceptibility to endotoxin shock ( J:137868 )

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:137868 )

• reduced susceptibility to hepatosteatosis after 19 weeks on high fat diet

• transgenic mice present fewer lipid droplets in the liver than controls following 19 weeks on high fat diet