Phenotypes associated with this allele

• Allele Symbol: Tenm2^tm1Cal
• Allele Name: targeted mutation 1, Catherine A Leamey
• Allele ID: MGI:5529622
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tenm2^tm1Cal/Tenm2^tm1Cal	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5529623

Genotype
MGI:5529623

hm1

• Allelic Composition: Tenm2^tm1Cal/Tenm2^tm1Cal
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:199791 )

• significant decrease in the area of the ventrotemporal crescent of the retina

abnormal retina ganglion layer morphology ( J:199791 )

• loss of ipsilaterally projecting retinal ganglion cells is seen in a subregion of the ventrotemporal crescent of the retina

• contralateral projecting retinal ganglion cells cover an expanded region in the ventral retina

abnormal visual evoked potential ( J:199791 )

• when the stimuli is presented in the pericentral region within the binocular zone, binocular responses are not consistently larger than contralateral responses the same mice

• binocular and ipsilateral responses appear smaller in magnitude on average compared with those in wild-type mice

• the alignment of traces is less apparent for VEPs that are maximally responsive to stimuli presented at the pericentral portion of the binocular zone

abnormal vision ( J:199791 )

• the dorsal discrimination threshold is significantly lower compared to wild-type controls

nervous system

abnormal superior colliculus morphology ( J:199791 )

• decrease in the proportion of the superior colliculus occupied by ipsilateral retinocollicular projections

abnormal lateral geniculate nucleus morphology ( J:199791 )

• the volume of the dorsal lateral geniculate nucleus occupied by ipsilateral retinogeniculate projections is slightly but significantly reduced

• the reduction is more notable in rostral sections compared to caudal sections

abnormal visual cortex morphology ( J:199791 )

• a slight, but significant reduction in the ipsilateral signal area and mediolateral ipsilateral signal width in the primary visual cortex indicating a reduction in the degree of ipsilateral input

abnormal sensory neuron innervation pattern ( J:199791 )

• the volume of the dorsal lateral geniculate nucleus occupied by ipsilateral retinogeniculate projections is slightly but significantly reduced

• the reduction of ipsilateral retinogeniculate projections is more notable in rostral sections compared to caudal sections

• decrease in the proportion of the superior colliculus occupied by ipsilateral retinocollicular projections