Phenotypes associated with this allele

• Allele Symbol: Ccn1^tm3.1Lfl
• Allele Name: targeted mutation 3.1, Lester F Lau
• Allele ID: MGI:5529625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccn1^tm3.1Lfl/Ccn1^tm3.1Lfl Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S4/SvJae * C57BL/6 * DBA	MGI:5529807

Genotype
MGI:5529807

cn1

• Allelic Composition: Ccn1^tm3.1Lfl/Ccn1^tm3.1Lfl; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:204032 )

N • mice exhibit normal liver morphology and outcome after partial hepatectomy

liver fibrosis ( J:204032 )

• CCl4-treated mice exhibit prominent central-to-central bridging fibrosis and a 4-fold increase more fibrotic area of collagen deposition in hydroxyproline accumulation compared with control mice

• 3 weeks following bile duct ligation, mice exhibit a 3-fold increase in fibrotic area compared with wild-type mice

homeostasis/metabolism

increased susceptibility to injury ( J:204032 )

• CCl4-treated mice exhibit prominent central-to-central bridging fibrosis, a 4-fold increase more fibrotic area of collagen deposition, 3-fold increase in hydroxyproline accumulation and fewer senescence cells around the central vein compared with control mice

• 3 weeks following bile duct ligation, mice exhibit a 3-fold increase in fibrotic area and hydroxyproline content and fewer senescent cells compared with wild-type mice

• however, CCl4-treated mice exhibit normal level of liver damage (serum alanine aminotransferase, cell proliferation and cell apoptosis) and myofibroblast apoptosis

cellular

abnormal cellular replicative senescence ( J:204032 )

• fewer senescence cells surrounding the hepatic central veins in CCl4-treated mice