Phenotypes associated with this allele

• Allele Symbol: Timm22^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5529629
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timm22^tm1b(KOMP)Wtsi/Timm22^tm1b(KOMP)Wtsi	B6N(Cg)-Timm22^tm1b(KOMP)Wtsi/J	MGI:5757809
hm2	Timm22^tm1b(KOMP)Wtsi/Timm22^tm1b(KOMP)Wtsi	C57BL/6N-Timm22^tm1b(KOMP)Wtsi/JMmucd	MGI:6376190
ht3	Timm22^tm1b(KOMP)Wtsi/Timm22^+	B6N(Cg)-Timm22^tm1b(KOMP)Wtsi/J	MGI:5757808

Genotype
MGI:5757809

hm1

• Allelic Composition: Timm22^{tm1b(KOMP)Wtsi}/Timm22^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Timm22^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0035_1_C02

Data Sources

IMPC Data for Timm22

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6376190

hm2

• Allelic Composition: Timm22^{tm1b(KOMP)Wtsi}/Timm22^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Timm22^{tm1b(KOMP)Wtsi}/JMmucd
• Cell Lines: EPD0035_1_C02

Timm22^{tm1b(KOMP)Wtsi}/Timm22^{tm1b(KOMP)Wtsi} mice exhibit embryonic lethality, with the expected number of embryos at E7.5 but no embryos at E9.5. Embryos at E7.5 are small and form a rudimentary egg-cylinder but show no primitive streak formation or hallmarks of gastrulation.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

Genotype
MGI:5757808

ht3

• Allelic Composition: Timm22^{tm1b(KOMP)Wtsi}/Timm22⁺
• Genetic Background: B6N(Cg)-Timm22^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0035_1_C02

Data Sources

IMPC Data for Timm22

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

increased circulating sodium level ( J:211773 )

♂

IMPC - JAX