Phenotypes associated with this allele

• Allele Symbol: Smoc2^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5529632
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smoc2^tm1.1(KOMP)Vlcg/Smoc2^tm1.1(KOMP)Vlcg	C57BL/6N-Smoc2^tm1.1(KOMP)Vlcg/J	MGI:5797828
hm2	Smoc2^tm1.1(KOMP)Vlcg/Smoc2^tm1.1(KOMP)Vlcg	involves: C57BL/6J * C57BL/6NTac * CBA	MGI:6117709
hm3	Smoc2^tm1.1(KOMP)Vlcg/Smoc2^tm1.1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6150824

Genotype
MGI:5797828

hm1

• Allelic Composition: Smoc2^{tm1.1(KOMP)Vlcg}/Smoc2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Smoc2^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 16694B-G5

Data Sources

IMPC Data for Smoc2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body length ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating phosphate level ( J:211773 )

♂

IMPC - JAX

increased circulating sodium level ( J:211773 )

♂

IMPC - JAX

integument

abnormal coat appearance ( J:211773 )

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - JAX

decreased bone mineral content ( J:211773 )

♀

IMPC - JAX

decreased bone mineral density ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:6117709

hm2

• Allelic Composition: Smoc2^{tm1.1(KOMP)Vlcg}/Smoc2^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac * CBA
• Cell Lines: 16694B-G5

homeostasis/metabolism

decreased susceptibility to injury ( J:244221 )

• mice subjected to unilateral ureteral obstruction or treated with FA exhibit protection from kidney fibrosis with reduced interstitial myofibroblast accumulation compared with wild-type mice

Genotype
MGI:6150824

hm3

• Allelic Composition: Smoc2^{tm1.1(KOMP)Vlcg}/Smoc2^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

craniofacial

decreased cranium length ( J:255774 )

• rostrocaudal shortening of skull

increased cranium width ( J:255774 )

• mediolateral widening of skull

decreased palatal length ( J:255774 )

• hard palate

digestive/alimentary system

decreased palatal length ( J:255774 )

• hard palate

growth/size/body

decreased palatal length ( J:255774 )

• hard palate

mortality/aging

mortality/aging ( J:255774 )

N • viable

reproductive system

reproductive system phenotype ( J:255774 )

N • fertile

skeleton

decreased cranium length ( J:255774 )

• rostrocaudal shortening of skull

increased cranium width ( J:255774 )

• mediolateral widening of skull