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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pik3c3tm1Tssk
targeted mutation 1, Takehiko Sasaki
MGI:5529808
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pik3c3tm1Tssk/Pik3c3tm1Tssk
Tg(Cryaa-cre)10Mlr/0
involves: FVB/N MGI:5529810


Genotype
MGI:5529810
cn1
Allelic
Composition
Pik3c3tm1Tssk/Pik3c3tm1Tssk
Tg(Cryaa-cre)10Mlr/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3tm1Tssk mutation (0 available); any Pik3c3 mutation (48 available)
Tg(Cryaa-cre)10Mlr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cataracts and impaired differentiation of secondary lens fiber cells in Pik3c3tm1Tssk/Pik3c3tm1Tssk Tg(Cryaa-cre)10Mlr/0 mice

homeostasis/metabolism
• inhibited autophagy in the lens at E16

vision/eye
• inhibited autophagy in the lens at E16
• impaired differentiation of secondary lens fiber cells with accumulation of vacuoles
• however, organelle degradation is normal
• bilateral at P0.5
• at P0.5, P7.5 and 2 months
• at birth and more pronounced at 2 months

cellular
• inhibited autophagy in the lens at E16





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory