Phenotypes associated with this allele

• Allele Symbol: Ass1^tm1.1Ekoe
• Allele Name: targeted mutation 1.1, Eleonore Kohler
• Allele ID: MGI:5529834
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ass1^tm1.1Ekoe/Ass1^tm1.1Ekoe	involves: 129P2/OlaHsd	MGI:5529837
ht2	Ass1^tm1.1Ekoe/Ass1^tm1.2Ekoe	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:5529838
cn3	Ass1^tm1.1Ekoe/Ass1^tm1.1Ekoe Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5529839

Genotype
MGI:5529837

hm1

• Allelic Composition: Ass1^tm1.1Ekoe/Ass1^tm1.1Ekoe
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203474 )

• mice are healthy and fertile

Genotype
MGI:5529838

ht2

• Allelic Composition: Ass1^tm1.1Ekoe/Ass1^tm1.2Ekoe
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:203474 )

• mice are healthy and fertile

Genotype
MGI:5529839

cn3

• Allelic Composition: Ass1^tm1.1Ekoe/Ass1^tm1.1Ekoe; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

homeostasis/metabolism

abnormal amino acid level ( J:203474 )

• citrulline production in the splanchnic region is doubled while arginine production is abolished

• suckling mice exhibit premature induction of the post-weaning pattern of amino acid metabolism in the liver

abnormal circulating amino acid level ( J:203474 )

• aorta veins exhibit increased circulating levels of glutamate, alanine and taurine compared with wild-type mice

• portal veins exhibit increased circulating glutamine, threonine, alanine, taurine, valine and leucine compared with wild-type mice

• renal veins exhibit decreased circulating levels of alanine, taurine, valine, isoleucine and, leucine compared with wild-type mice

• hepatic veins exhibit decreased circulating levels of glutamate, valine, isoleucine. Tryptophan and leucine compared with wild-type mice

• however, circulating lysine levels are normal

decreased circulating arginine level ( J:203474 )

• decreased circulating arginine levels in the hepatic and renal vein but not aorta and portal vein

increased circulating citrulline level ( J:203474 )

• increased circulating citrulline (arginine precursor) levels in the aorta and hepatic vein (1.5-fold) and portal and renal veins (2-fold)

decreased circulating ornithine level ( J:203474 )

• decreased circulating ornithine levels in the hepatic vein

increased circulating ornithine level ( J:203474 )

• increased circulating ornithine levels in the renal vein

decreased circulating taurine level ( J:203474 )

• renal veins exhibit decreased circulating levels of taurine compared with wild-type mice

increased circulating taurine level ( J:203474 )

• aorta veins exhibit increased circulating levels of taurine compared with wild-type mice

• portal veins exhibit increased circulating levels of taurine compared with wild-type mice

digestive/alimentary system

abnormal enterocyte morphology ( J:203474 )

• enterocytes exhibit altered amino acid fluxes compared with wild-type cells

growth/size/body

growth/size/body region phenotype ( J:203474 )

N • normal body weight

immune system

immune system phenotype ( J:203474 )

N • normal Peyer's patch development

integument

integument phenotype ( J:203474 )

N • normal hair growth