All Phenotypes Axin2<tm1.1(cre/ERT2/tdTomato)Eem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Axin2^{tm1.1(cre/ERT2/tdTomato)Eem}
targeted mutation 1.1, Edward E Morrisey
MGI:5532194

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Axin2^{tm1.1(cre/ERT2/tdTomato)Eem}/Axin2⁺ Ctnnb1^tm2Kem/Ctnnb1^tm2Kem	involves: 129S2/SvPas * C57BL/6	MGI:5532656

Allelic Composition	Axin2^{tm1.1(cre/ERT2/tdTomato)Eem}/Axin2⁺ Ctnnb1^tm2Kem/Ctnnb1^tm2Kem
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin2^{tm1.1(cre/ERT2/tdTomato)Eem} mutation (0 available); any Axin2 mutation (44 available)
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell proliferation ( J:204142 )

• epidermis where Ctnnb1 is deleted (following tamoxifen induction) exhibits significantly reduced cell proliferation (>40%) relative to control epidermis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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