Analysis Tools
mortality/aging
| N |
• born at expected Mendelian ratios
• survive to adulthood
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behavior/neurological
| N |
• no seizure-like movements
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• smaller amplitude of horizontal optico kinetic reflex gain but timing is normal
• no adaptive increase in horizontal optico kinetic reflex gain at 10 weeks after 1 hour of exposure to screen oscillations
|
nervous system
| N |
• cerebellar morphology is more or less normal
• climbing fiber distribution is normal at 10 weeks of age
• no abnormal enlargement of parallel fiber presynaptic terminals
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• fewer dendritic branching points
• increased spine density in the distal dendritic region
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• soma is smaller at 10 weeks of age but no degeneration is apparent
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• thin at 10 weeks of age
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• significantly increased parallel fiber EPSP at 10 weeks of age
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• induction of long term depression by stimulation of parallel fibers and climbing fibers is blocked
• long term depression by direct depolarization of Purkinje cells is blocked
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vision/eye
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• smaller amplitude of horizontal optico kinetic reflex gain but timing is normal
• no adaptive increase in horizontal optico kinetic reflex gain at 10 weeks after 1 hour of exposure to screen oscillations
|
