Phenotypes associated with this allele

• Allele Symbol: P3h1^tm1.1Brle
• Allele Name: targeted mutation 1.1, Brendan Lee
• Allele ID: MGI:5532323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P3h1^tm1.1Brle/P3h1^tm1.1Brle	involves: 129S7/SvEvBrd * C57BL/6	MGI:5532355

Genotype
MGI:5532355

hm1

• Allelic Composition: P3h1^tm1.1Brle/P3h1^tm1.1Brle
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal bone collagen fibril morphology ( J:204353 )

• skin exhibits smaller collagen fibril diameter as compared to wild type control

• fibrils are more homogenous in size than controls

decreased bone mineral density ( J:204353 )

• reduced trabecular bone mineral density as compared to wild type controls

abnormal trabecular bone morphology ( J:204353 )

• increased trabecular separation/spacing as compared to wild type controls

decreased trabecular bone volume ( J:204353 )

• decreased ratio of bone volume over tissue volume (BV/TV) as compared to controls

decreased bone trabecula number ( J:204353 )

decreased trabecular bone mass ( J:204353 )

• as compared to wild type controls, however cortical bone is similar to control

decreased trabecular bone thickness ( J:204353 )