Phenotypes associated with this allele

• Allele Symbol: Ubr4^tm1.1Nkt
• Allele Name: targeted mutation 1.1, Yoshihiro Nakatani
• Allele ID: MGI:5532331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5532400

Genotype
MGI:5532400

hm1

• Allelic Composition: Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation in E9.5-E12.5 Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203460 )

• fewer than expected mice are present after E11.5 with no mice detected at E13.5

embryo

abnormal placental labyrinth vasculature morphology ( J:203460 )

• dilated and disorganized maternal blood vessels full of serum and with monocytes marginated along the endothelial inner lining

decreased embryo size ( J:203460 )

• beginning at E10.5

thin placenta labyrinth ( J:203460 )

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:203460 )

• dilated and disorganized maternal blood vessels full of serum and with monocytes marginated along the endothelial inner lining

growth/size/body

decreased embryo size ( J:203460 )

• beginning at E10.5