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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmi1tm1.1Lees
targeted mutation 1.1, Jacqueline A Lees
MGI:5532395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bmi1tm1.1Lees/Bmi1tm1.1Lees involves: 129S4/SvJae * C57BL/6 MGI:5704436
cn2
 		Bmi1tm1.1Lees/Bmi1tm1.1Lees
Apctm2Cip/Apc+
Tg(Vil1-cre)20Syr/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:5532577


Genotype
MGI:5704436
hm1
Allelic
Composition		 Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1tm1.1Lees mutation (1 available); any Bmi1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:204354 )
• mice are viable and fertile




Genotype
MGI:5532577
cn2
Allelic
Composition		 Bmi1tm1.1Lees/Bmi1tm1.1Lees
Apctm2Cip/Apc+
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Cip mutation (0 available); any Apc mutation (157 available)
Bmi1tm1.1Lees mutation (1 available); any Bmi1 mutation (31 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased alimentary system tumor incidence ( J:204354 )
• reduced visible and total lesions in the small intestine

digestive/alimentary system
decreased alimentary system tumor incidence ( J:204354 )
• reduced visible and total lesions in the small intestine

cellular
cellular phenotype ( J:204354 )
N
• no increase in apoptosis is observed in non tumor tissue




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory